FcγRIIb Inhibits Allergic Lung Inflammation in a Murine Model of Allergic Asthma 英文参考文献.docVIP

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FcγRIIb Inhibits Allergic Lung Inflammation in a Murine Model of Allergic Asthma 英文参考文献.doc

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FcγRIIb Inhibits Allergic Lung Inflammation in a Murine Model of Allergic Asthma 英文参考文献

FccRIIbInhibitsAllergicLungInflammationinaMurine ModelofAllergicAsthma NileshDharajiya1,SwapnilV.Vaidya2,HirokiMurai2,VictorCardenas2,AlexanderKurosky3 ,Istvan Boldogh4,SanjivA.Sur2* 1NationalHeart,Lung,andBloodInstitute(NHLBI)ProteomicsCenter,DepartmentofBiochemistryandMolecularBiology,UniversityofTexasMedicalBranch,Galveston, Texas, United States ofAmerica, 2Departmentof Internal Medicine, University of TexasMedicalBranch, Galveston, Texas, United States of America, 3Department of BiochemistryandMolecularBiology,UniversityofTexasMedicalBranch,Galveston,Texas,UnitedStatesofAmerica,4DepartmentofMicrobiology,UniversityofTexas MedicalBranch,Galveston,Texas,UnitedStatesofAmerica Abstract Allergic asthma is characterized by airway eosinophilia, increased mucinproduction andallergen-specific IgE. Fcgamma receptor IIb (FccRIIb), an inhibitory IgG receptor, has recently emerged as a negative regulator of allergic diseases like anaphylaxisandallergicrhinitis.However,nostudiestodatehaveevaluateditsroleinallergicasthma.Ourmainobjective wastostudytheroleofFccRIIbinallergic lunginflammation.Weused amurine modelofallergicairwayinflammation. InflammationwasquantifiedbyBALinflammatorycellsandairwaymucinproduction.FccRIIbexpressionwasmeasuredby qPCR andflow cytometryandthecytokineswerequantifiedby ELISA.Compared towildtypeanimals,FccRIIb deficient mice mount a vigorous allergic lung inflammation characterized by increased bronchoalveolar lavage fluid cellularity, eosinophilia and mucin content upon ragweed extract (RWE) challenge. RWE challenge in sensitized mice upregulated FccRIIbinthelungs.DisruptionofIFN-cgeneabrogatedthisupregulation.Treatmentofna?¨vemicewiththeTh1-inducing agentCpGDNAincreasedFccRIIbexpressioninthelungs.Furthermore,treatmentofsensitizedmicewithCpGDNApriorto RWEchallengeinducedgreaterupregulationofFccRIIbthanRWEchallengealone.TheseobservationsindicatedthatRWE challengeupregulatedFccRIIbinthelungsbyIFN-c-andTh1-dependentmechanisms.RWEchallengeupreg