Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects 英文参考文献.docVIP

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Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects 英文参考文献.doc

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Fish Oil Supplementation Alters the Plasma Lipidomic Profile and Increases Long-Chain PUFAs of Phospholipids and Triglycerides in Healthy Subjects 英文参考文献

FishOilSupplementationAltersthePlasmaLipidomic ProfileandIncreasesLong-ChainPUFAsofPhospholipids andTriglyceridesinHealthySubjects IngerOttestad1,2,SaharHassani3,4,GretheI.Borge3,AchimKohler4,3,GjermundVogt3, TuuliaHyo¨tyla¨inen5,MatejOresˇicˇ5,KirstiW.Br?nner6,KirstenB.Holven2,StineM.Ulven1, MariC.W.Myhrstad1* 1DepartmentofHealth,NutritionandManagement,FacultyofHealthSciences,OsloandAkershusUniversityCollegeofAppliedSciences,Oslo,Norway,2Departmentof Nutrition,InstituteforBasicMedicalSciences,UniversityofOslo,Oslo,Norway,3Nofima,NorwegianInstituteofFood,FisheriesandAquacultureResearch,As,? Norway, 4Centre for Integrative Genetics (CIGENE), Department of Mathematical Sciences and Technology, Norwegian University of Life Science, As,? Norway, 5VTT Technical ResearchCentreofFinland,Espoo,Finland,6TINESA,CentreforResearchandDevelopment,Kalbakken,Oslo,Norway Abstract Background:Whilebeneficialhealtheffectsoffishandfishoilconsumptionarewelldocumented,theincorporationofn-3 polyunsaturatedfattyacidsinplasmalipidclassesisnotcompletelyunderstood.Theaimofthisstudywastoinvestigate theeffectoffishoilsupplementationontheplasmalipidomicprofileinhealthysubjects. Methodology/Principal Findings: In a double-blinded randomized controlled parallel-group study, healthy subjects received capsules containing either 8g/d of fish oil (FO) (1.6g/d EPA+DHA) (n=16) or 8g/d of high oleic sunflower oil (HOSO)(n=17)forsevenweeks.Duringthefirstthreeweeksofintervention,thesubjectscompletedafullycontrolleddiet period.BMIandtotalserumtriglycerides,total-,LDL-andHDL-cholesterolwereunchangedduringtheinterventionperiod. Lipidomic analyses were performed using Ultra Performance Liquid Chromatography (UPLC) coupled to electrospray ionizationquadrupoletime-of-flightmassspectrometry(QTOFMS),where568lipidsweredetectedand260identified.Both t-testsandMulti-BlockPartialLeastSquareRegression(MBPLSR)analysiswereperformedforanalysingdifferencesbetween the intervention groups. The intervention groups