Feasibility of Intensity-Modulated and Image-Guided Radiotherapy for Functional Organ Preservation in Locally Advanced Laryngeal Cancer 英文参考文献.docVIP

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Feasibility of Intensity-Modulated and Image-Guided Radiotherapy for Functional Organ Preservation in Locally Advanced Laryngeal Cancer 英文参考文献.doc

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Feasibility of Intensity-Modulated and Image-Guided Radiotherapy for Functional Organ Preservation in Locally Advanced Laryngeal Cancer 英文参考文献

FeasibilityofIntensity-ModulatedandImage-Guided RadiotherapyforFunctionalOrganPreservationin LocallyAdvancedLaryngealCancer NamP.Nguyen1*,AlexanderChi2,MichaelBetz3,FabioAlmeida4,PaulVos5,RickDavis1, BenjaminSlane1,MistyCeizyk1,DaveAbraham1,LexieSmith-Raymond1,MichelleStevie1, SiyoungJang6,StevenGelumbauskas1,VincentVinh-Hung3 1DepartmentofRadiationOncology,UniversityofArizona,Tucson,Arizona,UnitedStatesofAmerica,2DepartmentofRadiationOncology,UniversityofWestVirginia, Morgantown,WestVirginia,United StatesofAmerica, 3DepartmentofRadiationOncology,UniversityHospitalsofGeneva,Geneva,Switzerland, 4SouthwestPET/CT Institute, Tucson, Arizona, United States of America, 5Department of Biostatistics, East Carolina University, Greenville, North Carolina, United States of America, 6DepartmentofRadiationOncology,UniversityofPittsburgh,Pittsburgh,Pennsylvania,UnitedStatesofAmerica Abstract Purpose:Thestudyaimstoassessthefeasibilityofintensity-modulatedandimage-guidedradiotherapy(IMRT,andIGRT, respectively) for functional preservation in locally advanced laryngeal cancer. A retrospective review of 27 patients undergoingconcurrentchemoradiationforlocallyadvancedlaryngealcancers(8IMRT,19IGRT)wasundertaken.Inaddition toregularclinicalexaminations,allpatientshadPETimagingat4monthsand10monthsafterradiotherapy,thenyearly. Loco-regionalcontrol,speechqualityandfeeding-tubedependencywereassessedduringfollow-upvisits. Results: At a median follow-up of 20 months (range 6–57 months), four out of 27 patients (14.8%) developed local recurrence and underwent salvage total laryngectomy. One patient developed distant metastases following salvage surgery.Amongthe23patientswhoconservedtheirlarynxwithnosignofrecurrenceatlastfollow-up,22(95%)reported normalornearnormalvoicequality,allowingthemtocommunicateadequately.Fourpatients(14.8%)hadlong-termtube feeding-dependencybecauseofseveredysphagia(2patients)andchronicaspiration(2patients,withensuingdeathfrom aspirationpneumoniainonepatient). Co