Extensive Genetic Diversity, Unique Population Structure and Evidence of Genetic Exchange in the Sexually Transmitted Parasite Trichomonas vaginalis 英文参考文献.docVIP

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Extensive Genetic Diversity, Unique Population Structure and Evidence of Genetic Exchange in the Sexually Transmitted Parasite Trichomonas vaginalis 英文参考文献.doc

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Extensive Genetic Diversity, Unique Population Structure and Evidence of Genetic Exchange in the Sexually Transmitted Parasite Trichomonas vaginalis 英文参考文献

ExtensiveGeneticDiversity,UniquePopulationStructure andEvidenceofGeneticExchangeintheSexually TransmittedParasiteTrichomonasvaginalis MelissaD.Conrad1,AndrewW.Gorman1,JuliaA.Schillinger2,3,PierLuigiFiori4,RossanaArroyo5, NancyMalla6,MohanLalDubey6,JorgeGonzalez7,SusanBlank2,3,WilliamE.Secor8,JaneM.Carlton1* 1DepartmentofBiology,CenterforGenomicsandSystemsBiology,NewYorkUniversity,NewYork,NewYork,UnitedStatesofAmerica,2NewYorkCityDepartmentof HealthandMentalHygiene,BureauofSexuallyTransmittedDiseasesControl,NewYork,NewYork,UnitedStatesofAmerica,3DivisionofSexuallyTransmittedDisease Prevention,UnitedStatesCentersforDiseaseControlandPrevention,Atlanta,Georgia,UnitedStatesofAmerica,4DivisionofMicrobiology,DepartmentofBiomedical Sciences, University of Sassari, Sassari, Italy, 5Departamento de Infecto′mica y Patoge′nesis Molecular, Centro de Investigacio′n y de Estudios Avanzados del Instituto Polite′cnicoNacional(CINVESTAV-IPN),MexicoCity,Mexico,6DepartmentofParasitology,PostgraduateInstituteofMedicalEducationandResearch,Chandigarh,India, 7MolecularParasitologyUnit,FacultyofHealthSciences,UniversityofAntofagasta,Antofagasta,Chile,8DivisionofParasiticDiseasesandMalaria,CentersforDisease ControlandPrevention,Atlanta,Georgia,UnitedStatesofAmerica Abstract Background:Trichomonasvaginalisisthecausativeagentofhumantrichomoniasis,themostcommonnon-viralsexually transmittedinfectionworld-wide.Despiteitsprevalence,littleisknownaboutthegeneticdiversityandpopulationstructure ofthishaploidparasiteduetothelackofappropriatetools.ThedevelopmentofapanelofmicrosatellitemakersandSNPs from mining the parasite’s genome sequence has paved the way to a global analysis of the genetic structure of the pathogenandassociationwithclinicalphenotypes. Methodology/PrincipalFindings:HereweutilizeapanelofT.vaginalis-specificgeneticmarkerstogenotype235isolates from Mexico, Chile, India, Australia, Papua New Guinea, Italy, Africa and the United States, including 19 clinical isolates recentlycollectedfr