FoxO and Stress Responses in the Cnidarian Hydra vulgaris 英文参考文献.docVIP

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FoxO and Stress Responses in the Cnidarian Hydra vulgaris 英文参考文献.doc

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FoxO and Stress Responses in the Cnidarian Hydra vulgaris 英文参考文献

FoxOandStressResponsesintheCnidarian Hydravulgaris DianeBridge1*,AlexanderG.Theofiles1,RebeccaL.Holler1,EmilyMarcinkevicius2,RobertE.Steele3, DanielE.Mart?′nez2 1DepartmentofBiology,ElizabethtownCollege,Elizabethtown,Pennsylvania,UnitedStatesofAmerica,2DepartmentofBiology,PomonaCollege,Claremont,California, UnitedStatesofAmerica,3DepartmentofBiologicalChemistryandtheDevelopmentalBiologyCenter,UniversityofCaliforniaIrvine,Irvine,California,UnitedStatesof America Abstract Background: In the face of changing environmental conditions, the mechanisms underlying stress responses in diverse organisms are of increasing interest. In vertebrates, Drosophila, and Caenorhabditis elegans, FoxO transcription factors mediate cellular responses to stress, including oxidative stress and dietary restriction. Although FoxO genes have been identified in early-arising animal lineages including sponges and cnidarians, little is known about their roles in these organisms. Methods/PrincipalFindings:WehaveexaminedtheregulationofFoxOactivityinmembersofthewell-studiedcnidarian genusHydra.WefindthatHydraFoxOisexpressedathighlevelsincellsoftheinterstitiallineage,acelllineagethatincludes multipotent stemcells that giverise to neurons, stingingcells, secretory cells andgametes. Using transgenic Hydrathat expressaFoxO-GFPfusionproteinincellsoftheinterstitiallineage,wehavedeterminedthatheatshockcauseslocalization ofthefusionproteintothenucleus.Ourresultsalsoprovideevidencethat,asinbilateriananimals,HydraFoxOactivityis regulatedbybothAktandJNKkinases. Conclusions:ThesefindingsimplythatbasicmechanismsofFoxOregulationarosebeforetheevolutionofbilateriansand raisethepossibilitythatFoxOisinvolvedinstressresponsesofothercnidarianspecies,includingcorals. Citation:BridgeD,TheofilesAG,HollerRL,MarcinkeviciusE,SteeleRE,etal.(2010)FoxOandStressResponsesintheCnidarianHydravulgaris.PLoSONE5(7): e11686.doi:10.1371/journal.pone.0011686 Editor:AlexanderW.Shingleton,MichiganStateUniversity,UnitedStatesofAmerica Re