Fringe Controls Na?ve CD4+T Cells Differentiation through Modulating Notch Signaling in Asthmatic Rat Models 英文参考文献.docVIP
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FringeControlsNa?veCD4TCellsDifferentiationthroughModulatingNotchSignalinginAsthmaticRatModels英文参考文献
FringeControlsNa?¨veCD4+TCellsDifferentiation
throughModulatingNotchSignalinginAsthmaticRat
Models
WenGu,WeiguoXu,TaoDing,XuejunGuo*
DepartmentofRespiratoryMedicine,XinhuaHospital,ShanghaiJiaotongUniversity,SchoolofMedicine,Shanghai,China
Abstract
TheabilityofNotchsignalingtoregulateThelpercelldevelopmentanddifferentiationhasbeenwidelyaccepted.Fringe,O-
fucose-b1,3-N-acetylglucosaminyltransferases modulate Notch receptor expression and promote the Notch signaling
pathwaythroughreceptor-ligandbinding.Inthisstudy,weassayedtheexpressionlevelsofthreeFringehomologsinnaive
+
CD4 Tcellsinasthmaticrats.WefoundthatRadicalFringe(Rfng)washighlyexpressed,whereasbothLunaticFringe(Lfng)
andManicFringe(Mfng)wereexpressedatlowlevels.Down-regulationofRfngusingsiRNA,andoverexpressionofLfngor
MfngenhancedTh1subsetlineagesanddiminishedTh2subsetlineages.Notchsignalingwasmoreactivatedinasthmatic
na?¨veCD4 Tcellsthanincontrolcells,andLfng,butnotMfngorRfng,partlyinhibitedNotchsignalinginasthmaticna?¨ve
+
+
CD4 Tlymphocytes.LfngoverexpressionresultedinsignificantlydecreasedTh2cytokineproductioninasthma,whichwas
thesameeffectastheGSI(c-secretaseinhibitor)treatmentalone,buthadanincreasedeffectonTh1cytokinesthanGSI
treatment.Collectively,thesedataidentifytheessentialroleofFringemodulatingna?¨veCD4 Tcellsdifferentiationthrough
+
Notch signaling. Lfng regulated Th2 cells differentiation via a Notch-dependent manner and Th1 cells differentiation via
a Notch-independent manner. Fringe could be a therapeutic strategy for the management and prevention of allergic
asthma.
Citation:GuW,XuW,DingT,GuoX(2012)FringeControlsNa?¨veCD4+TCellsDifferentiationthroughModulatingNotchSignalinginAsthmaticRatModels.PLoS
ONE7(10):e47288.doi:10.1371/journal.pone.0047288
Editor:JianqingXu,FudanUniversity,China
ReceivedJune25,2012;AcceptedSeptember12,2012;PublishedOctober10,2012
Copyright:?2012Guetal.Thisisanopen-accessarticledistributedunderthetermsoftheCreativeCommonsAttributionLicense,whichpermitsunrestricted
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