Functional Brain Network Modularity Captures Inter- and Intra-Individual Variation in Working Memory Capacity 英文参考文献.docVIP

FunctionalBrainNetworkModularityCapturesInter-and Intra-IndividualVariationinWorkingMemoryCapacity AlexanderA.Stevens1,2*,SarahC.Tappon1,2,ArunGarg1,DamienA.Fair2 1DepartmentofPsychiatry,OregonHealthScienceUniversity,Portland,Oregon,UnitedStatesofAmerica,2DepartmentofBehavioralNeuroscience,OregonHealth ScienceUniversity,Portland,Oregon,UnitedStatesofAmerica Abstract Background:Cognitiveabilities,suchasworkingmemory,differamongpeople;however,individualsalsovaryintheirown day-to-day cognitive performance. One potential source of cognitive variability may be fluctuations in the functional organizationofneuralsystems.Thedegreetowhichtheorganizationofthesefunctionalnetworksisoptimizedmayrelate totheeffectivecognitivefunctioningoftheindividual.Herewespecificallyexaminehowchangesintheorganizationof large-scale networks measured via resting state functional connectivity MRI and graph theory track changes in working memorycapacity. Methodology/Principal Findings: Twenty-two participants performed a test of working memory capacity and then underwent resting-state fMRI. Seventeen subjects repeated the protocol three weeks later. We applied graph theoretic techniquestomeasurenetworkorganizationon34brainregionsofinterest(ROI).Networkmodularity,whichmeasuresthe levelofintegrationandsegregationacrosssub-networks,andsmall-worldness,whichmeasuresglobalnetworkconnection efficiency, both predicted individual differences in memory capacity; however, only modularity predicted intra-individual variation across the twosessions. Partial correlations controlling for thecomponent of working memorythat was stable across sessions revealed that modularity was almost entirely associated with the variability of working memory at each session.Analysesofspecificsub-networksandindividualcircuitswereunabletoconsistentlyaccountforworkingmemory capacityvariability. Conclusions/Significance: The results suggest that the intrinsic functional organization of an a priori defined cognitive controlnetworkm