Galectin-10, a Potential Biomarker of Eosinophilic Airway Inflammation 英文参考文献.docVIP

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Galectin-10, a Potential Biomarker of Eosinophilic Airway Inflammation 英文参考文献.doc

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Galectin-10, a Potential Biomarker of Eosinophilic Airway Inflammation 英文参考文献

Galectin-10,aPotentialBiomarkerofEosinophilicAirway Inflammation JustinC.Chua1,JoA.Douglass1*,AndrewGillman1,RobynE.O’Hehir1,ElsN.Meeusen2 1Department ofAllergy, Immunology andRespiratoryMedicine, TheAlfred Hospital andMonash University, Melbourne,Victoria, Australia, 2Biotechnology Research Laboratories,SchoolofBiomedicalSciences,MonashUniversity,Clayton,Victoria,Australia Abstract Measurementofeosinophilicairwayinflammationcanassistinthediagnosisofallergicasthmaandinthemanagementof exacerbations, however its clinical implementation remains difficult. Galectin-10 has been associated with eosinophilic inflammation and has the potential to be used as a surrogate biomarker. This study aimed to assess the relationship betweengalectin-10insputumwithsputumeosinophilcounts,thecurrentgoldstandardofeosinophilinflammationinthe lung. Thirty-eight sputum samples were processed for both eosinophil counts by cytospins and semi-quantitative measurementsofgalectin-10bywesternblots.Astrongassociationwasobservedbetweengalectin-10levelsinsputum and sputum eosinophil measurements, and they accurately determined sputum eosinophilia. The results support the potentialforgalectin-10tobeusedasasurrogatebiomarkerofeosinophilicairwayinflammation. Citation:ChuaJC,DouglassJA,GillmanA,O’HehirRE,MeeusenEN(2012)Galectin-10,aPotentialBiomarkerofEosinophilicAirwayInflammation.PLoSONE7(8): e42549.doi:10.1371/journal.pone.0042549 Editor:ChristianneBandeiradeMelo,InstitutodeBiofisicaCarlosChagasFilho,UniversidadeFederaldoRiodeJaneiro,Brazil ReceivedMay31,2012;AcceptedJuly10,2012;PublishedAugust6,2012 Copyright: ? 2012 Chua et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:FundingwasprovidedbyTheAustralianResearchCouncil.Thefunderhadnoroleinstudydesign,datacollectionandanalysis,decisiontopublish,or preparationofthema