Gamma-Glutamyltransferase Level and Risk of Hypertension A Systematic Review and Meta-Analysis 英文参考文献.docVIP

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Gamma-Glutamyltransferase Level and Risk of Hypertension A Systematic Review and Meta-Analysis 英文参考文献.doc

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Gamma-Glutamyltransferase Level and Risk of Hypertension A Systematic Review and Meta-Analysis 英文参考文献

Gamma-GlutamyltransferaseLevelandRiskof Hypertension:ASystematicReviewandMeta-Analysis Cun-FeiLiu.,Yu-TingGu.,Hai-YaWang,Ning-YuanFang* DepartmentofGeriatrics,RenjiHospital,ShanghaiJiaoTongUniversitySchoolofMedicine,Shanghai,China Abstract Background: Several prospective observational studies suggest that gamma-glutamyltransferase(GGT) level is positively associated with risk of hypertension. However, these studies draw inconsistent conclusions. Therefore, we conducted a systematicreviewandmeta-analysistoevaluatetheexactassociationbetweenGGTlevelandsubsequentdevelopmentof hypertension. Methods: We searched Pubmed, Embase,andScience Citation Index (ISI Webof Science)for prospective cohort studies examining the association between GGT level and hypertension. Then, pooled effect estimates (RRs) for the association betweenGGTlevelandhypertensionwerecalculated. Results: A total of 13 prospective cohort studies including 43314 participants and 5280 cases of hypertension were included.The pooledRRofhypertensionwas1.94(95%CI: 1.55–2.43; P,0.001)whencomparing theriskofhypertension betweenthehighestversuslowestcategoryofGGTlevels.Moreover,theriskofhypertensionincreasedby23%(summary RR: 1.23; 95%CI: 1.13–1.32; P,0.001) per 1 SD logGGT increment. Subgroup analyses showed significant positive associations in each subgroup except in §160/95 subgroup (RR: 2.56, 95%CI: 0.87–7.54; P=0.088) and nondrinkers subgroup(RR:1.76,95%CI:0.88–3.53;P=0.113).Sensitivityanalysesshowednosinglestudysignificantlyaffectsthepooled RRs.Nopublicationbiaswasfoundinourmeta-analysis. Conclusions: GGT level is positively associated with the development of hypertension. Further studies are needed to confirmourfindingsandelucidatetheexactmechanismsbetweenGGTlevelandtheincidenceofhypertension. Citation:LiuC-F,GuY-T,WangH-Y,FangN-Y(2012)Gamma-GlutamyltransferaseLevelandRiskofHypertension:ASystematicReviewandMeta-Analysis.PLoS ONE7(11):e48878.doi:10.1371/journal.pone.0048878 Editor:AntonyBayer,CardiffUnive