GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype Results from the TREP Project 英文参考文献.docVIP
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GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype Results from the TREP Project 英文参考文献
GATA-4andFOG-2ExpressioninPediatricOvarianSex
Cord-StromalTumorsReplicatesEmbryonalGonadal
Phenotype:ResultsfromtheTREPProject
CalogeroVirgone1*,GiovanniCecchetto1,AndreaFerrari2,GianniBisogno3,VittoriaDonofrio4,
RenataBoldrini5,PaolaCollini6,PatriziaDall’Igna1,RitaAlaggio7
1PediatricSurgery,DepartmentsofPediatricsandGynaecology-Obstetrics,UniversityHospital,Padua,Italy,2PediatricOncologyUnit,IstitutoNazionaleTumori,Milan,
Italy, 3Hematology Oncology, Departments of Pediatrics and Gynaecology-Obstetrics, University Hospital, Padua, Italy, 4Servizio di Anatomia e Istologia Patologica,
Azienda Ospedaliera di Rilievo Nazionale ‘‘Santobono Pausillipon’’, Naples, Italy, 5Pathology Unit, ‘‘Bambino Gesu`’’ Pediatric Hospital, Rome, Italy, 6Pathology Unit,
IstitutoNazionaleTumori,Milan,Italy,7PathologyUnit,DepartmentofMedicalandDiagnosticSciencesandSpecialTherapies,UniversityofPadua,Padua,Italy
Abstract
Aim: GATA proteins are a family of zinc finger transcription factors regulating gene expression, differentiation and
proliferationinvarioustissues.TheexpressionofGATA-4andFOG-2,oneofitsmodulators,wasstudiedinpediatricSex
Cord-Stromaltumorsoftheovary,inordertoevaluatetheirpotentialroleasdiagnosticmarkersandprognosticfactors.
Materials and Methods: Clinical and histological data of 15 patients, enrolled into the TREP Project since 2000 were
evaluated.Whenavailable,immunostainesforFOG-2,GATA-4,a-Inhibin,VimentinandPancytokeratinwerealsoanalyzed.
Results: Inour series there were6 Juvenile Granulosa Cell Tumors(JGCT), 6 Sertoli-Leydig Cell Tumors (SLCT), 1 Cellular
Fibroma,1ThecaCellTumorand1StromalSclerosingTumor(SST).Thirteenpatientsobtainedacompleteremission(CR),1
reachedasecondCRaftertheremovalofametachronoustumorand1diedofdisease.Inhibinwasdetectablein11/15,
Vimentinin13/15,Pancytokeratinin6/15,GATA-4in5/13andFOG-2in11/15.FOG-2washighlyexpressedin5/6JGCT,
whileGATA-4wasweaklydetectableonlyin1ofthecases.SLCTexpresseddiffuselyFOG-2(4/6)andGATA-4(3/5).GATA-4
andFOG-2weredetec
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