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GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype Results from the TREP Project 英文参考文献.docVIP

GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype Results from the TREP Project 英文参考文献.doc

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GATA-4 and FOG-2 Expression in Pediatric Ovarian Sex Cord-Stromal Tumors Replicates Embryonal Gonadal Phenotype Results from the TREP Project 英文参考文献

GATA-4andFOG-2ExpressioninPediatricOvarianSex Cord-StromalTumorsReplicatesEmbryonalGonadal Phenotype:ResultsfromtheTREPProject CalogeroVirgone1*,GiovanniCecchetto1,AndreaFerrari2,GianniBisogno3,VittoriaDonofrio4, RenataBoldrini5,PaolaCollini6,PatriziaDall’Igna1,RitaAlaggio7 1PediatricSurgery,DepartmentsofPediatricsandGynaecology-Obstetrics,UniversityHospital,Padua,Italy,2PediatricOncologyUnit,IstitutoNazionaleTumori,Milan, Italy, 3Hematology Oncology, Departments of Pediatrics and Gynaecology-Obstetrics, University Hospital, Padua, Italy, 4Servizio di Anatomia e Istologia Patologica, Azienda Ospedaliera di Rilievo Nazionale ‘‘Santobono Pausillipon’’, Naples, Italy, 5Pathology Unit, ‘‘Bambino Gesu`’’ Pediatric Hospital, Rome, Italy, 6Pathology Unit, IstitutoNazionaleTumori,Milan,Italy,7PathologyUnit,DepartmentofMedicalandDiagnosticSciencesandSpecialTherapies,UniversityofPadua,Padua,Italy Abstract Aim: GATA proteins are a family of zinc finger transcription factors regulating gene expression, differentiation and proliferationinvarioustissues.TheexpressionofGATA-4andFOG-2,oneofitsmodulators,wasstudiedinpediatricSex Cord-Stromaltumorsoftheovary,inordertoevaluatetheirpotentialroleasdiagnosticmarkersandprognosticfactors. Materials and Methods: Clinical and histological data of 15 patients, enrolled into the TREP Project since 2000 were evaluated.Whenavailable,immunostainesforFOG-2,GATA-4,a-Inhibin,VimentinandPancytokeratinwerealsoanalyzed. Results: Inour series there were6 Juvenile Granulosa Cell Tumors(JGCT), 6 Sertoli-Leydig Cell Tumors (SLCT), 1 Cellular Fibroma,1ThecaCellTumorand1StromalSclerosingTumor(SST).Thirteenpatientsobtainedacompleteremission(CR),1 reachedasecondCRaftertheremovalofametachronoustumorand1diedofdisease.Inhibinwasdetectablein11/15, Vimentinin13/15,Pancytokeratinin6/15,GATA-4in5/13andFOG-2in11/15.FOG-2washighlyexpressedin5/6JGCT, whileGATA-4wasweaklydetectableonlyin1ofthecases.SLCTexpresseddiffuselyFOG-2(4/6)andGATA-4(3/5).GATA-4 andFOG-2weredetec

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