Gene Responses to Oxygen Availability in Kluyveromyces lactis an Insight on the Evolution of the Oxygen-Responding System in Yeast 英文参考文献.docVIP

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Gene Responses to Oxygen Availability in Kluyveromyces lactis an Insight on the Evolution of the Oxygen-Responding System in Yeast 英文参考文献.doc

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Gene Responses to Oxygen Availability in Kluyveromyces lactis an Insight on the Evolution of the Oxygen-Responding System in Yeast 英文参考文献

GeneResponsestoOxygenAvailabilityinKluyveromyces lactis:anInsightontheEvolutionofthe Oxygen-RespondingSysteminYeast Zi-AnFang1,4.,Guang-HuiWang2,5.,Ai-LianChen3,You-FangLi1,Jian-PingLiu4,Yu-YangLi4 ,Monique Bolotin-Fukuhara1,Wei-GuoBao1* 1Universite′ ParisSud-11,CNRSUMR8621,InstitutdeGe′ne′tiqueetMicrobiologie,Orsay,France,2SchoolofMathematics,ShandongUniversity,Jinan,Shandong,China, 3Department of Mathematics, Fuzhou University,Fuzhou, Fujian, China, 4Institute of Genetics, State KeyLaboratory ofGeneticEngineering, School of Life Sciences, FudanUniversity,Shanghai,China,5LaboratoireMathe′matiques Applique′es auxSyste`mes,EcoleCentraleParis,Cha?tenay-Malabry, France Abstract The whole-genome duplication (WGD) may provide a basis for the emergence of the very characteristic life style of Saccharomyces cerevisiae—its fermentation-oriented physiology and its capacity of growing in anaerobiosis. Indeed, we foundanover-representationofoxygen-respondinggenesintheohnologsofS.cerevisiae.Manyoftheseduplicatedgenes arepresentasaerobic/hypoxic(anaerobic)pairsandformaspecializedsystemrespondingtochangingoxygenavailability. HYP2/ANB1 and COX5A/COX5B are such gene pairs, and their unique orthologs in the ‘non-WGD’ Kluyveromyces lactis genome behaved like the aerobic versions of S. cerevisiae. ROX1 encodes a major oxygen-responding regulator in S. cerevisiae.Thesynteny,structuralfeaturesandmolecularfunctionofputativeKlROX1wereshowntobedifferentfromthat ofROX1.ThetransitionfromtheK.lactis-typeROX1totheS.cerevisiae-typeROX1couldlinkupwiththedevelopmentof anaerobesintheyeastevolution.BioinformaticsandstochasticanalysesoftheRox1p-bindingsite(YYYATTGTTCTC)inthe upstreamsequencesofthe S.cerevisiae Rox1p-mediatedgenesandoftheK.lactis orthologsalsoindicated thatK.lactis lacksthespecificgenesystemrespondingtooxygenlimitingenvironment,whichispresentinthe‘post-WGD’genomeofS. cerevisiae.Thesedatasuggestedthattheoxygen-respondingsystemwasbornforthespecializedphysiologyofS.cerevisiae