Gene-Environment Interaction in the Onset of Eczema in Infancy Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure 英文参考文献.docVIP

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Gene-Environment Interaction in the Onset of Eczema in Infancy Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure 英文参考文献.doc

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Gene-Environment Interaction in the Onset of Eczema in Infancy Filaggrin Loss-of-Function Mutations Enhanced by Neonatal Cat Exposure 英文参考文献

o PL SMEDICINE Gene-EnvironmentInteractionintheOnsetof EczemainInfancy:FilaggrinLoss-of-Function MutationsEnhancedbyNeonatalCatExposure Hans Bisgaard1*,Angela Simpson2,Colin N.A. Palmer3,Klaus B?nnelykke1,Irwin Mclean3,Somnath Mukhopadhyay4, Christian B.Pipper1,Liselotte B.Halkjaer1,Brian Lipworth5,Jenny Hankinson2,Ashley Woodcock2,Adnan Custovic2 1CopenhagenProspectiveStudiesonAsthmainChildhood,DanishPaediatricAsthmaCentre,Copenhagen,UniversityHospitalGentofte,Copenhagen,Denmark,2School of Translational Medicine, University of Manchester, University Hospital of South Manchester National Health Service Foundation Trust, Manchester, United Kingdom, 3 Population Pharmacogenetics Group, Biomedical Research Centre, Ninewells Hospital and Medical School, University of Dundee, Dundee, United Kingdom, 4 Royal AlexandraChildren’sHospital,BrightonandSussexMedicalSchool,Brighton,UnitedKingdom,5AsthmaandAllergyResearchGroup,DivisionofMedicineandTherapeutics, NinewellsHospitalandMedicalSchool,UniversityofDundee,Scotland,UnitedKingdom Funding:CopenhagenStudyon AsthmainChildhood(COPSAC)is fundedbyresearchfunds.Themain fundsare:theLundbeckFoundation; thePharmacyFoundationof1991; AugustinusFoundation;andthe DanishMedicalResearchCouncil. ManchesterAsthmaandAllergy Study(MAAS)isfundedbythe MoultonCharitableTrustand AsthmaUK.ASissupportedbythe Collins’CharitableTrust.Thefunders didnothaveanyroleinstudy design,datacollectionandanalysis, decisiontopublish,orpreparation ofthemanuscript. ABSTRACT Background Loss-of-function variants in the gene encoding filaggrin (FLG) are major determinants of eczema. We hypothesized that weakening of the physical barrier in FLG-deficient individuals may potentiate the effect of environmental exposures. Therefore, we investigated whether thereisaninteractionbetweenFLGloss-of-functionmutationswithenvironmentalexposures (petsanddustmites)inrelationtothedevelopmentofeczema. MethodsandFindings Weuseddataobtainedinearlylifeinahigh-riskbirthcohortinDenm