Genetic Association of Multiple Sclerosis with the Marker rs391745 near the Endogenous Retroviral Locus HERV-Fc1 Analysis of Disease Subtypes 英文参考文献.docVIP

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Genetic Association of Multiple Sclerosis with the Marker rs391745 near the Endogenous Retroviral Locus HERV-Fc1 Analysis of Disease Subtypes 英文参考文献.doc

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Genetic Association of Multiple Sclerosis with the Marker rs391745 near the Endogenous Retroviral Locus HERV-Fc1 Analysis of Disease Subtypes 英文参考文献

GeneticAssociationofMultipleSclerosiswiththeMarker rs391745neartheEndogenousRetroviralLocusHERV- Fc1:AnalysisofDiseaseSubtypes BettinaHansen1,AnnetteB.Oturai2,HanneF.Harbo3,4,ElisabethG.Celius3,KariK.Nissen1, MagdalenaJ.Laska1,HelleB.S?ndergaard2,ThorPetersen5,Bj?rnA.Nex?1* 1Department of Biomedicine, Aarhus University, Aarhus C, Denmark, 2Danish Multiple Sclerosis Center, Department of Neurology, Copenhagen University Hospital Rigshospitalet, Copenhagen, Denmark, 3Department of Neurology, Oslo University Hospital, Oslo, Norway, 4Institute of Clinical Medicine, University of Oslo, Oslo, Norway,5Neurology,AarhusUniversityHospital,AarhusC,Denmark Abstract We have previously described the occurrence of multiple sclerosis (MS) to be associated with human endogenous retroviruses,specificallytheX-linkedvirallocusHERV-Fc1.Theaimofthisstudywastoinvestigateapossibleassociationof theHERV-Fc1locuswithsubtypesofMS.MSpatientsaregenerallysubdividedintothreecategories:Remitting/Relapsing andSecondaryProgressive,whichtogetherconstituteBoutOnsetMS,andPrimaryProgressive.Inthisstudyof1181MS patientsand1886controlswefoundthatBoutOnsetMSwasassociatedwiththeC-alleleofthemarkerrs391745nearthe HERV-Fc1 locus (p=0.003), while primary progressive disease was not. The ability to see genetic differences between subtypesofMSnearthisgenespeaksfortheinvolvementofthevirusHERV-Fc1locusinmodifyingthediseasecourseof MS. Citation: Hansen B, Oturai AB, Harbo HF, Celius EG, Nissen KK, et al. (2011) Genetic Association of Multiple Sclerosis with the Marker rs391745 near the EndogenousRetroviralLocusHERV-Fc1:AnalysisofDiseaseSubtypes.PLoSONE6(10):e26438.doi:10.1371/journal.pone.0026438 Editor:WelkinE.Johnson,HarvardMedicalSchool,UnitedStatesofAmerica ReceivedJuly25,2011;AcceptedSeptember27,2011;PublishedOctober25,2011 Copyright: ? 2011 Hansen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreprod