Genetic Prediction of Future Type 2 Diabetes 英文参考文献.docVIP

o Openaccess,freelyavailableonline PL S MEDICINE GeneticPredictionofFutureType2Diabetes Valeriya Lyssenko1*,Peter Almgren1,Dragi Anevski1,2,Marju Orho-Melander1,Marketa Sjo¨gren1,Carola Saloranta3,4, Tiinamaija Tuomi3,4,Leif Groop1,the Botnia Study Group 1DepartmentofClinicalSciences,DiabetesandEndocrinology,LundUniversity,UniversityHospitalMalmo¨,Malmo¨,Sweden,2SchoolofMathematicalSciences,Chalmers UniversityofTechnology,Gothenburg,Sweden,3DepartmentofMedicine,DivisionofDiabetology,HelsinkiUniversityHospital,Helsinki,Finland,4Folkha¨lsan Research Center,InstituteofGenetics,Helsinki,Finland CompetingInterests:LGisa memberoftheeditorialboardof PLoSMedicine. ABSTRACT Background AuthorContributions:VLextracted, genotyped,andanalyzedthedata, anddraftedthereport.PAandDA wereresponsibleforthestatistical analyses,MOMandMSfor Type2diabetes(T2D)isamultifactorialdiseaseinwhichenvironmentaltriggersinteractwith geneticvariantsinthepredispositiontothedisease.Anumberofcommonvariantshavebeen associatedwithT2DbutourknowledgeoftheirabilitytopredictT2Dprospectivelyislimited. genotyping,andCSandTTforthe phenotypedata.LGdesignedthe studyandsupervisedallpartsofthe workincludingdraftingthefinal report.Allresearcherstookpartin therevisionofthereportand MethodsandFindings ByusingaCoxproportionalhazardmodel,commonvariantsinthePPARG(P12A),CAPN10 (SNP43and44),KCNJ11(E23K),UCP2(à866G.A),andIRS1(G972R)geneswerestudiedfortheir abilitytopredictT2Din2,293individualsparticipatingintheBotniastudyinFinland.Aftera median follow-up of 6 y, 132 (6%) persons developed T2D. The hazard ratio for risk of developingT2Dwas1.7(95%confidenceinterval[CI]1.1–2.7)forthePPARGPPgenotype,1.5 (95% CI 1.0–2.2) for the CAPN10 SNP44 TT genotype, and 2.6 (95% CI 1.5–4.5) for the approvedthefinalversion. AcademicEditor:Andrew Hattersley,PeninsularMedical School,Exeter,UnitedKingdom Citation:LyssenkoV,AlmgrenP, AnevskiD,Orho-MelanderM, Sjo¨grenM,etal.(2005)Genetic predictionoffuturetype2diabetes. PLoSMed2(1