Genetic Polymorphisms of Glutathione S-Transferase Genes GSTM1, GSTT1 and Risk of Hepatocellular Carcinoma 英文参考文献.docVIP

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Genetic Polymorphisms of Glutathione S-Transferase Genes GSTM1, GSTT1 and Risk of Hepatocellular Carcinoma 英文参考文献.doc

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Genetic Polymorphisms of Glutathione S-Transferase Genes GSTM1, GSTT1 and Risk of Hepatocellular Carcinoma 英文参考文献

GeneticPolymorphismsofGlutathioneS-Transferase GenesGSTM1,GSTT1andRiskofHepatocellular Carcinoma KangSong1.,JiayongYi2.,XizhongShen3*,YuCai3* 1Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China, 2Department of Orthopedics, Zhongshan Hospital, Fudan University,Shanghai,People’sRepublicofChina,3DepartmentofGastroenterology,ZhongshanHospital,FudanUniversity,Shanghai,People’sRepublicofChina Abstract Background:Anumberofcase-controlstudieswereconductedtoinvestigatetheassociationofglutathioneS-transferase (GST)geneticpolymorphismsandhepatocellularcarcinoma(HCC)risk.However,thesestudieshaveyieldedcontradictory results. We therefore performed a meta-analysis to derive a more precise estimation of the association between polymorphismsonGSTM1,GSTT1andHCC. Methodology/Prinicpal Findings: PubMed, EMBASE, ISI web of science and the CNKI databases were systematically searched to identify relevant studies. Data were abstracted independently by two reviewers. Odds ratios (ORs) and 95% confidenceintervals(95%CIs)wereusedtoassessthestrengthofassociation.Potentialsourcesofheterogeneitywerealso assessedbysubgroupanalysisandmeta-regression.FunnelplotsandEgger’slinearregressionwereusedtotestpublication biasamongthearticles.Atotalof34studiesincluding4,463casesand6,857controlswereincludedinthismeta-analysis.In acombinedanalysis,significantlyincreasedHCCriskswerefoundfornullgenotypeofGSTM1(OR=1.29,95%CI:1.06–1.58; P=0.01)andGSTT1(OR=1.43,95%CI:1.22–1.68;P,1025).Potentialsourcesofheterogeneitywereexploredbysubgroup analysisandmeta-regression.SignificantresultswerefoundinEastAsiansandIndianswhenstratifiedbyethnicity;whereas nosignificantassociationswerefoundamongCaucasiansandAfricanpopulations.Bypoolingdatafrom12studiesthat consideredcombinationsofGSTT1andGSTM1nullgenotypes,astatisticallysignificantincreasedriskforHCC(OR=1.88, 95%CI:1.41–2.50;P,1024)wasdetectedforindividualswithcombineddeletionmutationsinbothgenescomparedwith positivegenotypes.