Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis The Cardiovascular Risk in Young Finns Study 英文参考文献.docVIP

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Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis The Cardiovascular Risk in Young Finns Study 英文参考文献.doc

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Genetic Variants and Their Interactions in the Prediction of Increased Pre-Clinical Carotid Atherosclerosis The Cardiovascular Risk in Young Finns Study 英文参考文献

GeneticVariantsandTheirInteractionsinthePrediction ofIncreasedPre-ClinicalCarotidAtherosclerosis:The CardiovascularRiskinYoungFinnsStudy SebastianOkser1.,TerhoLehtima¨ki2.,LauraL.Elo1,3,NinaMononen2,NinaPeltonen2,MikaKa¨ho¨nen4, MarkusJuonala5,6,Yue-MeiFan2,JussiA.Hernesniemi2,TomiLaitinen7,Leo-PekkaLyytika¨inen2 ,Riikka Rontu2,CaritaEklund8,NinaHutri-Ka¨ho¨nen9,LeenaTaittonen10,MikkoHurme8,JormaS.A.Viikari5,11, OlliT.Raitakari6,12,TeroAittokallio1,3 * 1BiomathematicsResearchGroup,DepartmentofMathematics,UniversityofTurku,Turku,Finland,2DepartmentofClinicalChemistry,TampereUniversityHospitaland University of Tampere, Tampere, Finland, 3Data Mining and Modeling Group, Turku Centre for Biotechnology, Turku, Finland, 4Department of Clinical Physiology, TampereUniversityHospitalandUniversityofTampere,Tampere,Finland,5DepartmentofMedicine,TurkuUniversityCentralHospital,Turku,Finland,6ResearchCentre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland, 7Department of Clinical Physiology and Nuclear Medicine, Kuopio University HospitalandUniversityofEasternFinland,Kuopio,Finland,8DepartmentofMicrobiologyandImmunology,UniversityofTampere,Tampere,Finland,9Departmentof Pediatrics,TampereUniversityHospital,Tampere,Finland,10DepartmentofPediatrics,UniversityofOulu,Oulu,Finland,11DepartmentofMedicine,UniversityofTurku, Turku,Finland,12DepartmentofClinicalPhysiology,TurkuUniversityHospital,Turku,Finland Abstract Therelativecontributionofgeneticriskfactorstotheprogressionofsubclinicalatherosclerosisispoorlyunderstood.Itis likelythatmultiplevariantsareimplicatedinthedevelopmentofatherosclerosis,butthesubtlegenotypicandphenotypic differencesarebeyondthereachoftheconventionalcase-controldesignsandthestatisticalsignificancetestingprocedures beingusedinmostassociationstudies.Ourobjectiveherewastoinvestigatewhetheranalternativeapproach—inwhich commondisordersaretreatedasquantitativephenotypesthatarecontinuouslydistributedoverapopulation—canreveal pred