Genetic Variants at Newly Identified Lipid Loci Are Associated with Coronary Heart Disease in a Chinese Han Population 英文参考文献.docVIP

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Genetic Variants at Newly Identified Lipid Loci Are Associated with Coronary Heart Disease in a Chinese Han Population 英文参考文献.doc

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Genetic Variants at Newly Identified Lipid Loci Are Associated with Coronary Heart Disease in a Chinese Han Population 英文参考文献

GeneticVariantsatNewlyIdentifiedLipidLociAre AssociatedwithCoronaryHeartDiseaseinaChineseHan Population LiZhou1.,HuDing2.,XiaominZhang1,MeianHe1,SuliHuang1,YujunXu2,YingShi3,GuanglinCui2, LongxianCheng3,QingK.Wang4,FrankB.Hu5,DaowenWang2*,TangchunWu1* 1Institute ofOccupational MedicineandtheMinistryofEducation KeyLabofEnvironment andHealth,SchoolofPublicHealth,HuazhongUniversityofScienceand Technology,Wuhan,Hubei,China,2InstituteofHypertensionandDepartmentofInternalMedicine,TongjiHospital,HuazhongUniversityofScienceandTechnology, Wuhan,Hubei,China,3DepartmentofCardiology,UnionHospital,HuazhongUniversityofScienceandTechnology,Wuhan,Hubei,China,4KeyLaboratoryofMolecular Biophysics of the Ministry of Education, College of Life Science and Technology and Center for Human Genome Research, Huazhong University of Science and Technology,Wuhan,Hubei,China,5DepartmentofNutritionandEpidemiology,HarvardSchoolofPublicHealth,Boston,Massachusetts,UnitedStatesofAmerica Abstract Background:Recentgenome-wideassociationstudies(GWAS)havemappedseveralnovellociinfluencingbloodlipidlevels inCaucasians.Wesoughttoexplorewhetherthegeneticvariantsatnewlyidentifiedlipid-associatedlociwereassociated withCHDsusceptibilityinaChineseHanpopulation. Methodology/PrincipalFindings:Weconductedatwo-stagecase-controlstudyinaChineseHanpopulation.Thefirst-stage, consistingof1,376CHDcasesand1,376sexandage-frequencymatchedcontrols,examined5novellipid-associatedsingle- nucleotidepolymorphisms(SNPs)identifiedfromGWASamongCaucasiansinrelationtoCHDriskinChinese.Wethenvalidated significantSNPsinthesecond-stage,consistingof1,269casesand2,745controls.WealsotestedassociationsbetweenSNPs withinthefivenovellociandbloodlipidlevelsin4,121controls.WeidentifiedtwonovelSNPs(rs599839inCELSR2-PSRC1-SORT1 andrnNCAN-CILP2)thatweresignificantlyassociatedwithreducedCHDriskinChinese(oddsratios(95%confidence intervals) in the dominant model 0.76 (0.61-0.90; P=0.001), 0.67 (0.57-0.77; P=3.461028), respectively). Mul