HCV Coinfection Associated with Slower Disease Progression in HIV-Infected Former Plasma Donors Na？ve to ART 英文参考文献.docVIP

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HCV Coinfection Associated with Slower Disease Progression in HIV-Infected Former Plasma Donors Na？ve to ART 英文参考文献.doc

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HCV Coinfection Associated with Slower Disease Progression in HIV-Infected Former Plasma Donors Na？ve to ART 英文参考文献

HCVCoinfectionAssociatedwithSlowerDisease ProgressioninHIV-InfectedFormerPlasmaDonorsNa?¨ve toART XiaoyanZhang1.,JianqingXu1,2.,HongPeng1,YanMa1,LifengHan1,YuhuaRuan1,BingSu3 ,Ning Wang1,YimingShao1* 1StateKeyLaboratoryforInfectiousDiseasePreventionandControl,NationalCenterforAIDS/STDControlandPrevention,ChinaCDC,Beijing,China,2ShanghaiPublic Health ClinicalCenter theInstitutes ofBiomedicalSciences,Fudan University, Shanghai,China, 3Anhui Provincial CenterforDiseaseControl andPrevention, Hefei, China Abstract Background:ItremainscontroversialhowHCVcoinfectioninfluencesthediseaseprogressionduringHIV-1infection.This studyaimstodefinetheinfluenceofHCVinfectiononthereplicationofHIV-1andthediseaseprogressioninHIV-infected formerplasmadonors(FPDs)na?¨vetoART. Methodology/PrincipalFindings:168HIV-1-infectedFPDswereenrolledintoacohortstudyfromAnhuiprovinceincentral China, and thereafter monitored at month 3, 9, 15, 21 and 33. Fresh whole blood samples were used for CD4+ T-cell counting.TheirplasmasampleswerecollectedandstoredforquantificationofHIV-1viralloadsandfordeterminationof HCVandToxoplasma.Outof168HIV-infectedFBDs,11.9%(20cases),80.4%(135cases)and7.7%(13cases)wereinfected withHIV-1alone,HIV-1/HCVandHIV/HCV/Toxoplasma,respectively.Duringthe33-monthfollow-up,only35%(7outof20 cases)HIV-1mono-infectedsubjectsremainedtheirCD4+T-cellcountsabove200cells/mlandretainedonthecohortstudy, whichwassignificantlylowerthan56%(75outof135cases)forHIV/HCVgroupand69%(9outof13cases)forHIV/HCV/ Toxoplasmagroup(p,0.05).CD4+TcellsinHIVmonoinfectiongroupwereconsistentlylowerthanthatinHIV/HCVgroup (p=0.04,0.18,0.03and0.04forbaseline,month9,month21andmonth33visit,respectively).Inaccordancewiththose observations, HIV viral loads in HIV mono-infection group were consistently higher than that in HIV/HCV group though statisticalsignificanceswereonlyreachedatbaseline(p=0.04). Conclusions/Significance: These data indicated HCV coinfection with HIV-1 is associated with the slower disease progress