Granulocyte Colony-Stimulating Factor Protects Mice during Respiratory Virus Infections 英文参考文献.docVIP

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Granulocyte Colony-Stimulating Factor Protects Mice during Respiratory Virus Infections 英文参考文献.doc

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Granulocyte Colony-Stimulating Factor Protects Mice during Respiratory Virus Infections 英文参考文献

GranulocyteColony-StimulatingFactorProtectsMice duringRespiratoryVirusInfections TamarHermesh1¤,ThomasM.Moran1,DeepikaJain2,CarolinaB.Lo′pez1,2* 1DepartmentofMicrobiologyandImmunologyInstitute,MountSinaiSchoolofMedicine,NewYork,NewYork,UnitedStatesofAmerica,2DepartmentofPathobiology SchoolofVeterinaryMedicineandInstituteforImmunology,UniversityofPennsylvania,Philadelphia,Pennsylvania,UnitedStatesofAmerica Abstract A burst in the production of pro-inflammatory molecules characterizes the beginning of the host response to infection. Cytokines, chemokines, and growth factors work in concert to control pathogen replication and activate innate and adaptive immune responses. Granulocyte colony-stimulating factor (G-CSF) mobilizes and activates hematopoietic cells fromthebonemarrow,andithasbeenshowntomediatethegenerationofeffectiveimmunityagainstbacterialandfungal infections.G-CSFisproducedathighlevelsinthelungsduringinfectionwithinfluenzaandparainfluenzaviruses,butits roleduringtheseinfectionsisunknown.Hereweshowthatduringinfectionofmicewithanon-lethaldoseofinfluenzaor + Sendaivirus,G-CSFpromotestheaccumulationofactivatedLy6G granulocytesthatcontroltheextentofthelungpro- inflammatoryresponse.Remarkably,theseG-CSF-mediatedeffectsfacilitateviralclearanceandsustainmousesurvival. Citation:HermeshT,MoranTM,JainD,Lo′pezCB(2012)GranulocyteColony-StimulatingFactorProtectsMiceduringRespiratoryVirusInfections.PLoSONE7(5): e37334.doi:10.1371/journal.pone.0037334 Editor:BernhardRyffel,FrenchNationalCentreforScientificResearch,France ReceivedNovember23,2011;AcceptedApril19,2012;PublishedMay16,2012 Copyright: ? 2012 Hermesh et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbytheNationalInstitutesofHealthgrantsAI082970andAI41111toTMMandAI083481andAI083284toCBL.Thefunders hadnor