Health Education through Analogies Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil 英文参考文献.docVIP

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Health Education through Analogies Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil 英文参考文献.doc

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Health Education through Analogies Preparation of a Community for Clinical Trials of a Vaccine against Hookworm in an Endemic Area of Brazil 英文参考文献

HealthEducationthroughAnalogies:Preparationofa CommunityforClinicalTrialsofaVaccineagainst HookworminanEndemicAreaofBrazil MariaFlaviaGazzinelli1,LucasLobato1,LeonardoMatoso1,RenatoAvila1,RitadeCassiaMarques1 ,Ami ShahBrown2,RodrigoCorrea-Oliveira3,JeffreyM.Bethony4,DavidJ.Diemert2,4* 1School of Nursing, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, 2Albert B. Sabin Vaccine Institute, Washington, District of Columbia, UnitedStatesofAmerica,3CentrodePesquisasRene′Rachou,BeloHorizonte,MinasGerais,Brazil,4DepartmentofMicrobiology,ImmunologyandTropicalMedicine,The GeorgeWashingtonUniversity,Washington,DistrictofColumbia,UnitedStatesofAmerica Abstract Background:Obtaininginformedconsentforclinicaltrialsisespeciallychallengingwhenworkinginrural,resource-limited areas,wherethereareoftenhighlevelsofilliteracyandlackofexperiencewithclinicalresearch.Suchanarea,aremotefield siteinthenortheasternpartofthestateofMinasGerais,Brazil,iscurrentlybeingpreparedforclinicaltrialsofexperimental hookwormvaccines.Thisstudywasconductedtoassesswhetherspecialeducationaltoolscanbedevelopedtoincrease theknowledgeandcomprehensionofpotentialclinicaltrialparticipantsandtherebyenablethemtomaketrulyinformed decisionstoparticipateinsuchresearch. Methodology/PrincipalFindings:Aninformationalvideowasproducedtoexplaintheworkoftheresearchteamandthe firstplannedhookwormvaccinetrial,usingapedagogicalmethodbasedonanalogies.Seventy-twoadultslivinginarural communityofMinasGeraiswereadministeredastructuredquestionnairethatassessedtheirknowledgeofhookworm,of researchandoftheplannedhookwormvaccinetrial,aswellastheirattitudesandperceptionsabouttheresearchersand participationinfuturevaccinetrials.Thequestionnairewasadministeredbeforebeingshowntheeducationalvideoand two months after and the results compared. After viewing the video, significant improvements in knowledge related to hookworminfectionanditshealthimpactwereobserved:usingacompositescorecombiningrelatedquestionsforwhich corr