GRHL3GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program 英文参考文献.docVIP

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GRHL3GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program 英文参考文献.doc

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GRHL3GET1 and Trithorax Group Members Collaborate to Activate the Epidermal Progenitor Differentiation Program 英文参考文献

GRHL3/GET1andTrithoraxGroupMembersCollaborate toActivatetheEpidermalProgenitorDifferentiation Program AmeliaSotoHopkin1,2,WilliamGordon1,2,3,RachelHerndonKlein1,2,FranciscoEspitia2,KennethDaily4, MichaelZeller4,PierreBaldi3,4,BogiAndersen1,2,3 * 1DepartmentofBiologicalChemistry,UniversityofCaliforniaIrvine,Irvine,California,UnitedStatesofAmerica,2DepartmentofMedicine,UniversityofCaliforniaIrvine, Irvine, California, United States of America, 3Center for Complex Biological Systems, University of California Irvine, Irvine, California, United States of America, 4DepartmentofComputerScience,UniversityofCaliforniaIrvine,Irvine,California,UnitedStatesofAmerica Abstract TheantagonisticactionsofPolycombandTrithoraxareresponsibleforpropercellfatedeterminationinmammaliantissues. Intheepidermis,aself-renewingepithelium,previousworkhasshownthatreleasefromPolycombrepressiononlypartially explainsdifferentiationgeneactivation.WenowshowthatTrithoraxisalsoakeyregulatorofepidermaldifferentiation,not only through activation of genes repressed by Polycomb in progenitor cells, but also through activation of genes independent of regulation by Polycomb. The differentiation associated transcription factor GRHL3/GET1 recruits the ubiquitouslyexpressedTrithoraxcomplextoasubsetofdifferentiationgenes. Citation: Hopkin AS, Gordon W, Klein RH, Espitia F, Daily K, et al. (2012) GRHL3/GET1 and Trithorax Group Members Collaborate to Activate the Epidermal ProgenitorDifferentiationProgram.PLoSGenet8(7):e1002829.doi:10.1371/journal.pgen.1002829 Editor:WendyA.Bickmore,MedicalResearchCouncilHumanGeneticsUnit,UnitedKingdom ReceivedFebruary3,2012;AcceptedMay28,2012;PublishedJuly19,2012 Copyright: ? 2012 Hopkin et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,providedtheoriginalauthorandsourcearecredited. Funding:ThisworkwassupportedbyNIHgrantsAR44882(toBA),LM010235-01A1(to