Herbal Medicines for Parkinsons Disease A Systematic Review of Randomized Controlled Trials 英文参考文献.docVIP

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Herbal Medicines for Parkinsons Disease A Systematic Review of Randomized Controlled Trials 英文参考文献.doc

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Herbal Medicines for Parkinsons Disease A Systematic Review of Randomized Controlled Trials 英文参考文献

HerbalMedicinesforParkinson’sDisease:ASystematic ReviewofRandomizedControlledTrials Tae-HunKim1,2,Ki-HoCho1*,Woo-SangJung1,MyeongSooLee2 1DepartmentofCardiovascularNeurologicDiseases,CollegeofOrientalMedicine,KyungHeeUniversity,Seoul,SouthKorea,2KoreaInstituteofOrientalMedicine, Daejeon,SouthKorea Abstract Objective:Weconductedsystematicreviewtoevaluatecurrentevidenceofherbalmedicines(HMs)forParkinson’sdisease (PD). Methods: Alongwithhandsearches, relevantliteratures werelocated fromtheelectronicdatabases includingCENTRAL, MEDLINE, EMBASE, CINAHL, AMED, PsycInfo, CNKI, 7 Korean Medical Databases and J-East until August, 2010 without languageandpublicationstatus.Randomizedcontrolledtrials(RCTs),quasi-randomizedcontrolledtrialsandrandomized crossovertrials,whichevaluateHMsforidiopathicPDwereselectedforthisreview.Twoindependentauthorsextracted datafromtherelevantliteraturesandanydisagreementwassolvedbydiscussion. Results:Fromthe3432ofrelevantliteratures,64wereincluded.Wefailedtosuggestoverallestimatesoftreatmenteffects onPDbecauseofthewideheterogeneityofusedherbalrecipesandstudydesignsintheincludedstudies.Whencompared with placebo, specific effects were not observed in favor of HMs definitely. Direct comparison with conventional drugs suggestedthattherewasnoevidenceofbettereffectforHMs.Manystudiescomparedcombinationtherapywithsingle activedrugsandcombinationtherapyshowedsignificantimprovementinPDrelatedoutcomesanddecreaseinthedoseof anti-Parkinson’sdrugswithlowadverseeventsrate. Conclusion:Currently,thereisnoconclusiveevidenceabouttheeffectivenessandefficacyofHMsonPD.Forestablishing clinicalevidenceofHMsonPD,rigorousRCTswithsufficientstatisticalpowershouldbepromotedinfuture. Citation: Kim T-H, Cho K-H, Jung W-S, Lee MS (2012) Herbal Medicines for Parkinson’s Disease: A Systematic Review of Randomized Controlled Trials. PLoS ONE7(5):e35695.doi:10.1371/journal.pone.0035695 Editor:MarkR.Cookson,NationalInstitutesofHealth,UnitedStatesofAmerica ReceivedDecember6,2011;Acc