Heritability of P. falciparum and P. vivax Malaria in a Karen Population in Thailand 英文参考文献.docVIP

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Heritability of P. falciparum and P. vivax Malaria in a Karen Population in Thailand 英文参考文献.doc

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Heritability of P. falciparum and P. vivax Malaria in a Karen Population in Thailand 英文参考文献

HeritabilityofP.falciparumandP.vivaxMalariaina KarenPopulationinThailand WaraphonPhimpraphi1,2.,RichardPaul1.,BheeWitoonpanich1,3,ChairatTurbpaiboon1,3 ,Chayanon Peerapittayamongkol1¤,ChalisaLouicharoen1,IsabelleCasademont1,SumaleeTungpradabkul3, SrivichaKrudsood2,JaranitKaewkunwal2,ThanyachaiSura4,SornchaiLooareesuwan5 ,Pratap Singhasivanon2,AnavajSakuntabhai1,4* 1InstitutPasteur,LaboratoiredelaGe′ne′tiquedelare′ponseauxinfectionschezl’homme,Paris,France,2DepartmentofTropicalHygiene,FacultyofTropicalMedicine, MahidolUniversity,BangkokThailand,3Department ofBiochemistry,FacultyofScience,MahidolUniversity,Bangkok,Thailand, 4DepartmentofMedicine,Facultyof Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand, 5Department of Clinical Tropical Medicine, Faculty of Tropical Medicine, Mahidol University, Bangkok,Thailand Abstract Themajorityofstudiesconcerningmalariahostgeneticshavefocusedonindividualgenesthatconferprotectionagainst rather than susceptibility to malaria. Establishing the relative impact of genetic versus non-genetic factors on malaria infection and disease is essential to focus effort on key determinant factors. This relative contribution has rarely been evaluatedforPlasmodiumfalciparumandalmostneverforPlasmodiumvivax.Weconductedalongitudinalcohortstudyina Karenpopulationof3,484individualsinaregionofmesoendemicmalaria,Thailandfrom1998to2005.ThenumberofP. falciparum and P. vivax clinical cases and the parasite density per person were determined. Statistical analyses were performed to account for the influence of environmental factors and the genetic heritability of the phenotypes was calculated using the pedigree-based variance components model. The genetic contribution to the number of clinical episodes resulting from P. falciparum and P. vivax were 10% and 19% respectively. There was also moderate genetic contributiontothemaximumandoverallparasitetrophozoitedensityphenotypesforbothP.falciparum(16%16%)andP. vivax (15%13%). These va