High Prevalence of Vitamin D Deficiency in Pregnant Women A National Cross-Sectional Survey 英文参考文献.docVIP
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High Prevalence of Vitamin D Deficiency in Pregnant Women A National Cross-Sectional Survey 英文参考文献
HighPrevalenceofVitaminDDeficiencyinPregnant
Women:ANationalCross-SectionalSurvey
StefanieVandevijvere1*,SihameAmsalkhir2,HermanVanOyen1,RodrigoMoreno-Reyes2
1DepartmentofPublicHealthandSurveillance,ScientificInstituteofPublicHealth,Brussels,Belgium,2DepartmentofNuclearMedicine,Ho?pitalErasme,Universite′Libre
deBruxelles,Brussels,Belgium
Abstract
AnincreasingnumberofstudiessuggestthatvitaminDdeficiencyduringpregnancyisassociatedwithmultipleadverse
healthoutcomesinmothers,neonatesandchildren.TherearenorepresentativecountrydataavailableonvitaminDstatus
ofpregnantwomeninEurope.TheaimofthisstudywastoestimatetheprevalenceofvitaminDdeficiencyamongBelgian
pregnant women and to assess the determinants of vitamin D status in the first and third trimester of pregnancy. The
women were selected via a multi-stage proportionate-to-size sampling design. Blood samples were collected and
a questionnaire was completed face-to-face. 55 obstetric clinics were randomly selected and 1311 pregnant women
participatedinthestudy.Themedianserum25-hydroxyvitaminD[25-(OH)D]concentrationwassignificantlylowerinthe
firsttrimester(20.4ng/ml)thaninthirdtrimester(22.7ng/ml).Ofallwomen,74.1%(95%CI=71.8–76.5%)werevitaminD
insufficient (25-(OH)D ,30ng/ml), 44.6% (95%CI=41.9–47.3%) were vitamin D deficient (25-(OH)D ,20ng/ml), while
12.1% (95%CI=10.3–13.8%) were severely vitamin D deficient (25-(OH)D ,10ng/ml). Of all women included, 62.0%
reportedtakingvitaminD-containingmultivitamins,ofwhichonly24.2%startedtakingthosebeforepregnancy.Theriskof
vitaminDdeficiency(25-(OH)D,20ng/ml)wassignificantlyhigherforlesseducatedwomenandwomenwhoreportednot
goingonholidaystosunnyclimates.TheriskofseverevitaminDdeficiency(25-(OH)D,10ng/ml)decreasedforwomen
whoreportedalcoholconsumptionduringpregnancy,decreasedwithmorefrequentuseofsunscreenlotionandincreased
forsmokersandwomenwhoreportedpreferenceforshadow.Inconclusion,vitaminDdeficiencyishighlyprevalentamong
pregnantwomeninBelgiumandthisraisesconcernsaboutthehealthco
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