Herpes-Virus Infection in Patients with Langerhans Cell Histiocytosis A Case-Controlled Sero-Epidemiological Study, and In Situ Analysis 英文参考文献.docVIP

下载本文档

7
0
约3.34万字
约 8页
2017-05-11 发布于上海
举报
版权申诉

Herpes-Virus Infection in Patients with Langerhans Cell Histiocytosis A Case-Controlled Sero-Epidemiological Study, and In Situ Analysis 英文参考文献.doc

1、本文档共8页，可阅读全部内容。
2、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。
3、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击这里二次下载。
4、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
5、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
6、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
7、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
8、VIP文档为合作方或网友上传，每下载1次，网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档

Herpes-Virus Infection in Patients with Langerhans Cell Histiocytosis A Case-Controlled Sero-Epidemiological Study, and In Situ Analysis 英文参考文献

Herpes-VirusInfectioninPatientswithLangerhansCell Histiocytosis:ACase-ControlledSero-Epidemiological Study,andInSituAnalysis EricJeziorski1.,BrigitteSenechal1.,ThierryJoMolina1,2,FrancisDevez2,MarianneLeruez-Ville3 ,Patrice Morand4,ChristopheGlorion3,LudovicMansuy5,JoelGaudelus6,MarianneDebre3,FrancisJaubert1,3, Jean-MarieSeigneurin4,CarolineThomas7,IreneJoab8,JeanDonadieu9,FredericGeissmann1,3* 1Laboratoryofbiologyofthemononuclearphagocytesystem,INSERMU838,UniversityParis-Descartes,Paris,France,2Hopitaldel’HotelDieu,Pathologydepartment, AP-HP,Paris,France,3HopitalNecker-EnfantsMalades,AP-HP,Paris,France,4CentreHospitalo-UniversitaireMichallon,Virologydepartment,Grenoble,France,5Centre Hospitalo-UniversitairedeNancy,MedecineinfantileII,Nancy,France,6HopitalJeanVerdier,AP-HP,servicedePediatrie,Bondy,France,7CentreHospitalo-Universitaire de Nantes, Pediatrie, Nantes, France, 8UMR542 Inserm-Universite Paris Sud, Hopital Paul Brousse, Villejuif, France, 9Hopital d’Enfants Armand Trousseau, Pediatric Hematologyunit,Centredere′fe′rencedel’histiocytoseAP-HP,Paris,France Abstract Background: Langerhans cell histiocytosis (LCH) is a rare disease that affects mainly young children, and which features granulomascontainingLangerhans-typedendriticcells.Theroleofseveralhumanherpesviruses(HHV)inthepathogenesis ofLCHwassuggestedbynumerousreportsbutremainsdebated.Epstein-barrvirus(EBV,HHV-4),Cytomegalovirus(CMV, HHV-5)caninfectLangerhanscells,andEBV,CMVandHHV-6havebeenproposedtobeassociatedwithLCHbasedonthe detectionofthesevirusesinclinicalsamples. Methodology:WehaveinvestigatedtheprevalenceofEBV,CMVandHHV-6infection,thecharactersofantibodyresponse and the plasma viral load in a cohort of 83 patients and 236 age-matched controls, and the presence and cellular localizationofthevirusesinLCHtissuesamplesfrom19patients. PrincipalFindings:Theresultsshowthatprevalence,serologicaltiters,andviralloadforEBV,CMVandHHV-6didnotdiffer between patients and controls. EBV was found by PCR in tumo