Latent Cluster Analysis of ALS Phenotypes Identifies Prognostically Differing Groups 英文参考文献.docVIP

LatentClusterAnalysisofALSPhenotypesIdentifies PrognosticallyDifferingGroups JebanGanesalingam,DanielStahl,LokeshWijesekera,ClareGaltrey,ChristopherE.Shaw,P.Nigel Leigh,AmmarAl-Chalabi* DepartmentofClinicalNeuroscience,MRCCentreforNeurodegenerationResearch,King’sCollegeLondon,InstituteofPsychiatry,London,UnitedKingdom Abstract Background: Amyotrophic lateral sclerosis (ALS) is a degenerative disease predominantly affecting motor neurons and manifesting as several different phenotypes. Whether these phenotypes correspond to different underlying disease processesisunknown.Weusedlatentclusteran