Latent Factor Analysis to Discover Pathway-Associated Putative Segmental Aneuploidies in Human Cancers 英文参考文献.docVIP

LatentFactorAnalysistoDiscoverPathway-Associated PutativeSegmentalAneuploidiesinHumanCancers JosephE.Lucas1*,Hsiu-NiKung1,2,Jen-TsanA.Chi1,2 * 1InstituteforGenomeSciencesandPolicy,DukeUniversity,Durham,NorthCarolina,UnitedStatesofAmerica,2DepartmentofMolecularGeneticsandMicrobiology, DukeUniversity,Durham,NorthCarolina,UnitedStatesofAmerica Abstract Tumor microenvironmental stresses, such as hypoxia and lactic acidosis, play important roles in tumor progression. Although gene signatures reflecting the influence of these stresses are powerful approaches to link expression with phenotypes,they