Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results 英文参考文献.docVIP

LearningfromDecoystoImprovetheSensitivityand SpecificityofProteomicsDatabaseSearchResults AmitKumarYadav,DhirendraKumar,DebasisDash* GNRKnowledgeCenterforGenomeInformatics,CSIR-InstituteofGenomicsandIntegrativeBiology,Delhi,India Abstract Thestatisticalvalidationofdatabasesearchresultsisacomplexissueinbottom-upproteomics.Thecorrectandincorrect peptide spectrum match (PSM) scores overlap significantly, making an accurate assessment of true peptide matches challenging.Sincethecompleteseparationbetweenthetrueandfalsehitsispracticallyneverachieved,thereisneedfor better methods and rescoring algo