Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results 英文参考文献.docVIP

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Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results 英文参考文献.doc

Learning from Decoys to Improve the Sensitivity and Specificity of Proteomics Database Search Results 英文参考文献

LearningfromDecoystoImprovetheSensitivityand SpecificityofProteomicsDatabaseSearchResults AmitKumarYadav,DhirendraKumar,DebasisDash* GNRKnowledgeCenterforGenomeInformatics,CSIR-InstituteofGenomicsandIntegrativeBiology,Delhi,India Abstract Thestatisticalvalidationofdatabasesearchresultsisacomplexissueinbottom-upproteomics.Thecorrectandincorrect peptide spectrum match (PSM) scores overlap significantly, making an accurate assessment of true peptide matches challenging.Sincethecompleteseparationbetweenthetrueandfalsehitsispracticallyneverachieved,thereisneedfor better methods and rescoring algo

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