Large-Scale Analysis of Network Bistability for Human Cancers 英文参考文献.docVIP

Large-ScaleAnalysisofNetworkBistabilityforHuman Cancers TetsuyaShiraishi1*,ShinakoMatsuyama2,HiroakiKitano1,3,4 1Sony Computer Science Laboratories, Shinagawa-ku, Tokyo, Japan, 2Sony Corporation, Shinagawa-ku, Tokyo, Japan, 3The Systems Biology Institute, Shinjuku-ku, Tokyo,Japan,4OkinawaInstituteofScienceandTechnology,Kunigami,Okinawa,Japan Abstract Protein–proteininteractionandgeneregulatorynetworksarelikelytobelockedinastatecorrespondingtoadiseaseby the behavior of one or more bistable circuits exhibiting switch-like behavior. Sets of genes could be over-expressed or repressed when anomal