原创力文档LEDGFp75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors 英文参考文献.docVIP
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LEDGFp75 Proteins with Alternative Chromatin Tethers Are Functional HIV-1 Cofactors 英文参考文献
LEDGF/p75ProteinswithAlternativeChromatinTethers
AreFunctionalHIV-1Cofactors
AnneM.Meehan1,DyanaT.Saenz1,JamesH.Morrison1,JoseA.Garcia-Rivera2,MaryPeretz1 ,Manuel
Llano2,EricM.Poeschla1*
1DepartmentofMolecularMedicine,MayoClinicCollegeofMedicine,Rochester,Minnesota,UnitedStatesofAmerica,2BiologicalSciencesDepartment,Universityof
Texas,ElPaso,Texas,UnitedStatesofAmerica
Abstract
LEDGF/p75 can tether over-expressed lentiviral integrase proteins to chromatin but how this underlies its integration
cofactorrolefortheseretrovirusesisunclear.Whileasingleintegrasebindingdomain(IBD)bindsintegrase,aco
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