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Mathematical Description of Bacterial Traveling Pulses 英文参考文献
MathematicalDescriptionofBacterialTravelingPulses
JonathanSaragosti1.*, VincentCalvez2,3.*,NikolaosBournaveas4,AxelBuguin1,PascalSilberzan1,
Beno??tPerthame5,6
1Physico-Chimie-Curie,InstitutCurie,UMRCNRS168,Paris,France,2Unite′ deMathe′matiquesPuresetApplique′es,E′coleNormaleSupe′rieuredeLyon,UMRCNRS5669,
Lyon, France, 3NUMED, INRIA Rho?ne-Alpes, Montbonnot, Lyon, France, 4School of Mathematics, University of Edinburgh, Edinburgh, United Kingdom, 5Laboratoire
Jacques-LouisLions,Universite′ PierreetMarieCurie,UMRCNRS7598,Paris,France,6InstitutUniversitairedeFrance,Paris,France
Abstract
TheKeller-Segelsystemhasbeenwidelyproposedasamodelforbacterialwavesdrivenbychemotacticprocesses.Current
experiments on Escherichia coli have shown the precise structure of traveling pulses. We present here an alternative
mathematicaldescriptionoftravelingpulsesatthemacroscopicscale.Thismodelingtaskiscomplementedwithnumerical
simulationsinaccordancewiththeexperimentalobservations.Ourmodelisderivedfromanaccuratekineticdescriptionof
themesoscopicrun-and-tumbleprocessperformedbybacteria.Thiscanaccountforrecentexperimentalobservationswith
E. coli. Qualitative agreements include the asymmetry of the pulse and transition in the collective behaviour (clustered
motion versus dispersion). In addition, we can capture quantitatively the traveling speed of the pulse as well as its
characteristic length. This work opens several experimental and theoretical perspectives since coefficients at the
macroscopiclevelarederivedfromconsiderationsatthecellularscale.Forinstance,theparticularresponseofasinglecell
tochemicalcuesturnsouttohaveastrongeffectoncollectivemotion.Furthermore,thebottom-upscalingallowsusto
performpreliminarymathematical analysisandwriteefficientnumerical schemes.Thismodelisintendedasapredictive
toolfortheinvestigationofbacterialcollectivemotion.
Citation:SaragostiJ,CalvezV,BournaveasN,BuguinA,SilberzanP,etal.(2010)MathematicalDescriptionofBacterialTravelingPulses.PLoSComputBi
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