Metabolic Changes Reveal the Development of Schistosomiasis in Mice 英文参考文献.docVIP

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Metabolic Changes Reveal the Development of Schistosomiasis in Mice 英文参考文献.doc

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Metabolic Changes Reveal the Development of Schistosomiasis in Mice 英文参考文献

MetabolicChangesRevealtheDevelopmentof SchistosomiasisinMice JunfangWu1,2,WenxinXu1,2,ZhenpingMing3,HuifenDong3,HuiruTang1*,YulanWang1* 1StateKeyLaboratoryofMagneticResonanceandAtomicandMolecularPhysics,WuhanCenterforMagneticResonance,WuhanInstituteofPhysicsandMathematics, ChineseAcademyofSciences,Wuhan,People’sRepublicofChina,2GraduateSchoolofChineseAcademyofSciences,Beijing,People’sRepublicofChina,3Department ofMedicalParasitology,SchoolofBasicMedicalScience,WuhanUniversity,Wuhan,People’sRepublicofChina Abstract Schistosomiasisisaparasiticzoonosiscausedbysmalltrematodewormscalledschistosomes,amongstwhichSchistosoma japonicum (S. japonicum) is endemic in Asia. In order to understand the schistosome-induced changes in the host metabolism so as to facilitate early diagnosis of schistosomiasis, we systematically investigated the dynamic metabolic responses of mice biofluids and liver tissues to S. japonicum infection for five weeks using 1H NMR spectroscopy in conjunctionwithmultivariatedataanalysis.Wewereabletodetectschistosomiasisatthethirdweekpost-infection,which wasoneweekearlierthan‘‘goldstandard’’methods.WefoundthatS.japonicuminfectioncausedsignificantelevationof urinary 3-ureidopropionate, a uracil catabolic product, and disturbance of lipid metabolism, stimulation of glycolysis, depressionoftricarboxylicacidcycleanddisruptionofgutmicrobiotaregulations.Wefurtherfoundthatthechangesof3- ureidopropionateandoverallmetabolicchangesinbothurinaryandplasmasampleswerecloselycorrelatedwiththetime- courseofdiseaseprogression.Furthermore,suchchangestogetherwithlivertissuemetabonomewereclearlyassociated with the worm-burdens. These findings provided more insightful understandings of host biological responses to the infection and demonstrated that metabonomic analysis is potentially useful for early detection of schistosomiasis and comprehensionofthemechanisticaspectsofdiseaseprogression. Citation:WuJ,XuW,MingZ,DongH,TangH,etal.(2010)MetabolicChangesRevealtheDevelopmentofS