Mesenteric Resistance Arteries in Type 2 Diabetic dbdb Mice Undergo Outward Remodeling 英文参考文献.docVIP

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Mesenteric Resistance Arteries in Type 2 Diabetic dbdb Mice Undergo Outward Remodeling 英文参考文献.doc

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Mesenteric Resistance Arteries in Type 2 Diabetic dbdb Mice Undergo Outward Remodeling 英文参考文献

MesentericResistanceArteriesinType2Diabeticdb/db MiceUndergoOutwardRemodeling FlaviaM.Souza-Smith1,2,PaigeS.Katz3,4,5,AaronJ.Trask4,5,JamesA.Stewart,Jr.4,5,KevinC.Lord6, KurtJ.Varner1,DaltonV.Vassallo2,PamelaA.Lucchesi4,5* 1Department of Pharmacology and Experimental Therapeutics, Louisiana State University Health Sciences Center, New Orleans, Louisiana, United States of America, 2DepartmentofPhysiologicalSciences,FederalUniversityofEspiritoSanto,Vitoria,EspiritoSanto,Brazil,3DepartmentofPhysiology,LouisianaStateUniversityHealth SciencesCenter,NewOrleans,Louisiana,UnitedStatesofAmerica,4CenterforCardiovascularandPulmonaryResearchandTheHeartCenter,TheResearchInstituteat Nationwide Children’s Hospital, Columbus, Ohio, United States of America, 5Department of Pediatrics, The Ohio State University, Columbus, Ohio, United States of America,6FeikSchoolofPharmacy,UniversityoftheIncarnateWord,SanAntonio,Texas,UnitedStatesofAmerica Abstract Objective:Resistancevesselremodelingiscontrolledbymyriadofhemodynamicandneurohormonalfactors.Thisstudy characterizedstructuralandmolecularremodelinginmesentericresistancearteries(MRAs)indiabetic(db/db)andcontrol (Db/db)mice. Methods:StructuralpropertieswereassessedinisolatedMRAsfrom12and16wk-olddb/dbandDb/dbmicebypressure myography. Matrix regulatory proteins were measured by Western blot analysis. Mean arterial pressure and superior mesentericbloodflowweremeasuredin12wk-oldmicebytelemetryandaDopplerflownanoprobe,respectively. Results: Blood pressure was similar between groups. Lumen diameter and medial cross-sectional area were significantly increasedin16wk-olddb/dbMRAcomparedtocontrol,indicatingoutwardhypertrophicremodeling.Moreover,wallstress andcross-sectionalcomplianceweresignificantlylargerindiabeticarteries.Theseremodelingindiceswereassociatedwith increasedexpressionofmatrixregulatoryproteinsmatrixmetalloproteinase(MMP)-9,MMP-12,tissueinhibitorsofmatrix metalloproteinase (TIMP)-1, TIMP-2, and plasminogen activator inhibitor-1 (PA