Microbial Diversity of Genital Ulcer Disease in Men Enrolled in a Randomized Trial of Male Circumcision in Kisumu, Kenya 英文参考文献.docVIP

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Microbial Diversity of Genital Ulcer Disease in Men Enrolled in a Randomized Trial of Male Circumcision in Kisumu, Kenya 英文参考文献.doc

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Microbial Diversity of Genital Ulcer Disease in Men Enrolled in a Randomized Trial of Male Circumcision in Kisumu, Kenya 英文参考文献

MicrobialDiversityofGenitalUlcerDiseaseinMen EnrolledinaRandomizedTrialofMaleCircumcisionin Kisumu,Kenya SupriyaD.Mehta1*,StefanJ.Green2,IanMaclean3,HongHu4,RobertC.Bailey1,PatrickM.Gillevet5, GregT.Spear6 1Department of Epidemiology and Biostatistics, University of Illinois at Chicago School of Public Health, Chicago, Illinois, United States of America, 2DNA Services, Research Resources Center, University of Illinois at Chicago School of Medicine, Chicago, Illinois, United States of America, 3Department of Medical Microbiology, University of Manitoba, Manitoba, Winnipeg, Canada, 4Department of Bioinformatics, University of Illinois at Chicago, Chicago, Illinois, United States of America, 5DepartmentofEnvironmentalSciencesandPolicy,GeorgeMasonUniversity,Fairfax,Virginia,UnitedStatesofAmerica,6DepartmentofImmunologyandMicrobiology, RushUniversityMedicalCenter,Chicago,Illinois,UnitedStatesofAmerica Abstract Background:Medicalmalecircumcision(MMC)reducestheriskofgenitalulcerdisease(GUD)inmenby50%.InUgandan and Kenyan trials, a sexually transmissible agent was not identified in 50–60% of GUD specimens by polymerase chain reaction(PCR)assay.WesoughttobetterdefinetheetiologyofGUDinmenparticipatingintheKenyantrialandexamine howMMCaffectsGUDetiology. Methods:WedefinedGUDofunknownetiologyasnegativeforHSV(type1andtype2),T.pallidum,andH.ducreyibyPCR, andnegativeforHSV-2andT.pallidumbyserology.Weidentifiedbacterialmicrobiotainasubsetof59GUDspecimens using multitag pyrosequencing of the 16S rRNA gene, and compared results by unknown vs. STI-associated etiology. StatisticalanalysisemployedBray-Curtissimilaritymeasureofbacterialcommunitybyetiology,hierarchicalclusteringand logisticregression. Results: In 59 GUD specimens from 59 men, 23 (39%) had unknown etiology. Bacterial diversity was greater in GUD of unknownthanSTIetiology(p=0.01).Fusobacteria(Fusobacteriumspp.andSneathiaspp.)weremorecommonlydetected inmenwithGUDofunknownetiology[adjustedOR=5.67;95%CI:1.63–19.8]aswereOxobac