Molecular Evolution of Human H1N1 and H3N2 Influenza A Virus in Thailand, 2006–2009 英文参考文献.docVIP

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Molecular Evolution of Human H1N1 and H3N2 Influenza A Virus in Thailand, 2006–2009 英文参考文献.doc

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Molecular Evolution of Human H1N1 and H3N2 Influenza A Virus in Thailand, 2006–2009 英文参考文献

MolecularEvolutionofHumanH1N1andH3N2Influenza AVirusinThailand,2006–2009 KamolSuwannakarn1,ThaweesakChieochansin1,ChitimaThongmee1,JarikaMakkoch1 ,Kesmanee Praianantathavorn1,ApiradeeTheamboonlers1,SrinandSreevatsan2,YongPoovorawan1* 1Center of Excellence in Clinical Virology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, 2Departments of Veterinary Population Medicine and VeterinaryandBiomedicalSciences,UniversityofMinnesota,SaintPaul,Minnesota,UnitedStatesofAmerica Abstract Background:Annualseasonalinfluenzaoutbreaksareassociatedwithhighmorbidityandmortality. Objective:ToindexanddocumentevolutionarychangesamonginfluenzaAH1N1andH3N2virusesisolatedfromThailand during2006–2009,usingcompletegenomesequences. Methods: Nasopharyngeal aspirates were collected from patients diagnosed with respiratory illness in Thailand during 2006–2009.AllsampleswerescreenedforInfluenzaAvirus.Atotalof13H1N1and21H3N2wereconfirmedandwhole genomesequencedfortheevolutionaryanalysisusingstandardphylogeneticapproaches. Results:PhylogeneticanalysisofHArevealedacleardiversificationofseasonalfromvaccinestrainlineages.H3N2seasonal clusters were closely related to the WHO recommended vaccine strains in each season. Most H1N1 isolates could be differentiatedinto3lineages.TheA/Brisbane/59/2007lineage,avaccinestrainforH1N1since2008,iscloselyrelatedwith theH1N1subtypescirculatingin2009.HAsequenceswereconservedatthereceptor-bindingsite.Aminoacidvariationsin theantigenicsiteresulted inapossible N-linkedglycosylationmotif.RecentH3N2isolateshadhighergeneticvariations comparedtoH1N1isolates.MostsubstitutionsintheNPproteinwereclusteredintheT-cellrecognitiondomains. Conclusion:InthisstudyweperformedevolutionarygeneticanalysisofinfluenzaAvirusesinThailandbetween2006–2009. Althoughthecurrentvaccinestrainisefficientforcontrollingthecirculatingoutbreaksubtypes,surveillanceisnecessaryto provide unambiguous information on emergent viruses. In summary, the findings of this study contribute the