Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D 英文参考文献.docVIP

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Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D 英文参考文献.doc

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Molecular Genetic Analyses of Polytene Chromosome Region 72A-D in Drosophila melanogaster Reveal a Gene Desert in 72D 英文参考文献

MolecularGeneticAnalysesofPolyteneChromosome Region72A-DinDrosophilamelanogasterRevealaGene Desertin72D MonicaT.Cooper,JamesA.Kennison* ProgramonGenomicsofDifferentiation, EuniceKennedyShriverNationalInstitute ofChildHealth andHuman Development, NationalInstitutesofHealth, Bethesda, Maryland,UnitedStatesofAmerica Abstract We have investigated a region of ,310kb of genomic DNA within polytene chromosome subdivisions 72A to 72D of Drosophila melanogaster. This region includes 57 predicted protein-coding genes. Seventeen of these genes are in six clustersthatappeartohavearisenbytandemduplication.Withinthisregionwefound23complementationgroupsthatare essentialforzygoticviability,andwehaveidentifiedthetranscriptionunitsfor18ofthe23.Wealsofounda55kbregionin 72D that is nonessential. Flies deficient for this region are viable and fertile. Within this nonessential region are48 DNA sequences of 12 to 33 base pairs that are completely conserved among 12 distantly related Drosophila species. These sequences do not have the evolutionary signature of conserved protein-coding DNA sequences, nor do they appear to encode microRNAs, however, the strong selection suggests functions in wild populations that are not apparent in laboratorycultures.Thisregionresemblesdispensablegenedesertspreviouslycharacterizedinthemousegenome. Citation:CooperMT,KennisonJA(2011)MolecularGeneticAnalysesofPolyteneChromosomeRegion72A-DinDrosophilamelanogasterRevealaGeneDesertin 72D.PLoSONE6(8):e23509.doi:10.1371/journal.pone.0023509 Editor:TroyZars,UniversityofMissouri,UnitedStatesofAmerica ReceivedJune13,2011;AcceptedJuly19,2011;PublishedAugust10,2011 Thisisanopen-accessarticle,freeofallcopyright,andmaybefreelyreproduced,distributed,transmitted,modified,builtupon,orotherwiseusedbyanyonefor anylawfulpurpose.TheworkismadeavailableundertheCreativeCommonsCC0publicdomaindedication. Funding:ThisresearchwassupportedbytheIntramuralResearchProgramoftheNationalInstitutesofHealth,NICHD.Thefundershadnoroleinst