Monitoring HIV-1 Resistance across the Globe 英文参考文献.docVIP

Open access, freely available online Synopses of Research Articles The Complicated Art of Tracking Dengue DOI: 10.1371/journal.pmed.0020116 Compared with malaria, dengue fever has a rather lower pro?le in the public mind, although to those who have had it, it leaves a great impression. The name dengue fever is derived from the Swahiliwords Ki denga pepo (“it is a sudden overtaking by an evil spirit”), which gives an idea of the rapid onset of the disease.The dengue virus is carried by the mosquito Aedes aegypti, and the disease often occurs as epidemics. Although the classic illness is a fairly benign acute febrile syndrome, it may be very painful—hence the English nickname, breakbone fever.The virus can also cause a much more serious illness known as dengue hemorrhagic fever, which can progress to dengue shock syndrome.There are four main serotypes of the dengue RNA virus; dengue hemorrhagic fever is more likely to occur during dengue infection in people with preexisting active or passive (e.g., maternally acquired) immunity who are exposed to a different dengue virus serotype. In contrast to classic dengue, the hemorrhagic fever and shock syndromes are mostly diseases of children and, if untreated, have a mortality of around 50%. might want to plan for dengue outbreaks, though they do go some way to helping to understand the complex interplay between the various factors. In essence, the researchers found that there was a signi?cant association between El Ni?o oscillations, climate variables, and dengue hemorrhagic fever incidence with a 2- to 3-year repeat, for both Bangkok and the rest of Thailand. However this association was signi?cant only for the years 1986–1992, and outside these years factors other than climate were probably responsible for triggering the disease outbreaks. DOI: 10.1371/journal.pmed.0020116.g001 Aedes aegypti, the main vector of dengue (Photo: CDC/Robert S Craig) Bernard Cazelles and colleagues looked at the details of the relationshi