Multiple Insecticide Resistance in Anopheles gambiae s.l. Populations from Burkina Faso, West Africa 英文参考文献.docVIP

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Multiple Insecticide Resistance in Anopheles gambiae s.l. Populations from Burkina Faso, West Africa 英文参考文献.doc

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Multiple Insecticide Resistance in Anopheles gambiae s.l. Populations from Burkina Faso, West Africa 英文参考文献

MultipleInsecticideResistanceinAnophelesgambiaes.l. PopulationsfromBurkinaFaso,WestAfrica MoussaNamountougou1*,Fre′de′ricSimard1,2,ThierryBaldet2,3,4,AbdoulayeDiabate′1 ,Jean BoscoOue′draogo1,ThibaudMartin2,3,4,RochK.Dabire′1 1Institut de Recherche en Sciences de la Sante′/Centre Muraz, Bobo-Dioulasso, Burkina Faso, West Africa, 2Maladies Infectieuses et Vecteurs: Ecologie, Ge′ne′tique, EvolutionetContro?le,InstitutdeRecherchepourleDe′veloppement,Montpellier,France,3CentredeRechercheEntomologiquedeCotonou,Cotonou,Be′nin,4Centrede Coope′ration InternationaleenRechercheAgronomiquepourleDe′veloppement,Montpellier,France Abstract Malariacontrolprogramsarebeingjeopardizedbythespreadofinsecticideresistanceinmosquitovectorpopulations.The situation in Burkina Faso is emblematic with Anopheles gambiae populations showing high levels of resistance to most availablecompounds.Althoughthefrequencyofinsecticidetarget-sitemutationsincludingknockdownresistance(kdr)and insensitive acetylcholinesterase (Ace-1R) alleles has been regularly monitored in the area, it is not known whether detoxifyingenzymescontributetothediversityofresistancephenotypesobservedinthefield.Here,weproposeanupdate onthephenotypicdiversityofinsecticideresistanceinAn.gambiaepopulationssampledfrom10sitesinBurkinaFasoin 2010.Susceptibilitytodeltamethrin,permethrin, DDT,bendiocarbandfenithrotionwasassessed. Testspecimens (N=30 perlocality)wereidentifiedtospeciesandmolecularformandtheirgenotypeatthekdrandAce-1lociwasdetermined. Detoxifying enzymes activities including non-specific esterases (NSEs), oxydases (cytochrome P450) and Glutathione S- Transferases (GSTs) were measured on single mosquitoes (N=50) from each test locality and compared with the An. gambiae Kisumu susceptible reference strain. In all sites, mosquitoes demonstrated multiple resistance phenotypes, showing reduced mortality to several insecticidal compounds at the same time, although with considerable site-to-site variation.Boththekdr1014La