Mutational Biases and Selective Forces Shaping the Structure of Arabidopsis Genes 英文参考文献.docVIP

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Mutational Biases and Selective Forces Shaping the Structure of Arabidopsis Genes 英文参考文献.doc

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Mutational Biases and Selective Forces Shaping the Structure of Arabidopsis Genes 英文参考文献

MutationalBiasesandSelectiveForcesShapingthe StructureofArabidopsisGenes SalvatoreCamiolo,DomenicoRau,AndreaPorceddu* DipartimentodiScienzeAgronomicheeGeneticaVegetaleAgraria(DISAGEVA),Universita` degliStudidiSassari,Sassari,Italy Abstract Recently features of gene expression profiles have been associated with structural parameters of gene sequences in organisms representing a diverse set of taxa. The emerging picture indicates that natural selection, mediated by gene expressionprofiles,hasasignificantroleindetermininggenicstructures.Howeverthecurrentsituationislessclearinplants astheavailabledataindicatesthattheeffectofnaturalselectionmediatedbygeneexpressionisveryweak.Moreover,the directionofthepatternsinplantsappearstocontradictthoseobservedinanimalgenomes.Inthepresentworkweanalized expressiondatafor.18000Arabidopsisgenesretrievedfrompublicdatasetsobtainedwithdifferenttechnologies(MPSS and high density chip arrays) and compared them with gene parameters. Our results show that the impact of natural selection mediated by expression on genes sequences is significant and distinguishable from the effects of regional mutational biases. In addition, we provide evidence that the level and the breadth of gene expression are related in oppositewaystomanystructuralparametersofgenesequences.Higherlevelsofexpressionabundanceareassociatedwith smaller transcripts, consistent with the need to reduce costs of both transcription and translation. Expression breadth, however, shows a contrasting pattern, i.e. longer genes have higher breadth of expression, possibly to ensure those structuralfeaturesassociatedwithgeneplasticity.Basedontheseresults,weproposethatthespecificbalancebetween thesetwoselectiveforcesplayasignificantroleinshapingthestructureofArabidopsisgenes. Citation: Camiolo S, Rau D, Porceddu A (2009) Mutational Biases and Selective Forces Shaping the Structure of Arabidopsis Genes. PLoS ONE 4(7): e6356. doi:10.1371/journal.pone.0006356 Editor:Pa¨r K.Ingvarsson,Uni