Nasal Bone Shape Is under Complex Epistatic Genetic Control in Mouse Interspecific Recombinant Congenic Strains 英文参考文献.docVIP
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Nasal Bone Shape Is under Complex Epistatic Genetic Control in Mouse Interspecific Recombinant Congenic Strains 英文参考文献
NasalBoneShapeIsunderComplexEpistaticGenetic
ControlinMouseInterspecificRecombinantCongenic
Strains
Gae′tanBurgio1,2,3*,MichelBaylac4,EvelyneHeyer2,XavierMontagutelli1
1Institut Pasteur, Unite′ de Ge′ne′tique Fonctionnelle de la Souris, CentreNational de la Recherche Scientifique,URA 2578, Paris, France, 2Unite′ d’Eco-Anthropologie,
e′quipe,Ge′ne′tique desPopulationsHumaines,CentreNationaldelaRechercheScientifique,MuseumNationald’HistoireNaturelle,Universite′ Paris7,UMR7206,Paris,
France,3DepartmentofGenetics,MenziesResearchInstitute,UniversityofTasmania,Hobart,Tasmania,Australia,4Organisation,StructureetEvolutiondelaBiodiversite′
UMR5202etPlateformedeMorphome′trie,CentreNationaldelaRechercheScientifiqueIFR101etUMR5202,Laboratoired’EntomologieduMuse′umNationald’Histoire
Naturelle,Paris,France
Abstract
Background:Geneticdeterminismofcranialmorphologyinthemouseisstilllargelyunknown,despitethelocalizationof
putativeQTLsandtheidentificationofgenesassociatedwithMendelianskullmalformations.Toapproachthedissectionof
thismultigeniccontrol,wehaveusedasetofinterspecificrecombinantcongenicstrains(IRCS)producedbetweenC57BL/6
andmiceofthedistantspeciesMusspretus(SEG/Pas).Eachstrainhasinherited1.3%ofitsgenomefromSEG/Pasunderthe
formoffew,small-sized,chromosomalsegments.
Results:TheshapeofthenasalbonewasstudiedusingoutlineanalysiscombinedwithFourierdescriptors,anddifferential
featureswereidentifiedbetweenIRCSBcG-66HandC57BL/6.AnF2crossbetweenBcG-66HandC57BL/6revealedthat,out
ofthethreeSEG/Pas-derivedchromosomalregionspresentinBcG-66H,twowereinvolved.Segmentsonchromosomes1
(,32Mb)and18(,13Mb)showedadditiveeffectonnasalboneshape.ThethreechromosomalregionspresentinBcG-
66H were isolated in congenic strains to study their individual effect. Epistatic interactions were assessed in bicongenic
strains.
Conclusions:Ourresultsshowthat,besidesastrongindividualeffect,theQTLonchromosome1interactswithgeneson
chromosomes 13 and 18. This study demonstrates that nasal bone shape is unde
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