Neurogenesis Response of Middle-Aged Hippocampus to Acute Seizure Activity 英文参考文献.docVIP

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Neurogenesis Response of Middle-Aged Hippocampus to Acute Seizure Activity 英文参考文献.doc

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Neurogenesis Response of Middle-Aged Hippocampus to Acute Seizure Activity 英文参考文献

NeurogenesisResponseofMiddle-AgedHippocampusto AcuteSeizureActivity AshokK.Shetty1,2,3,4*.,BharathiHattiangady1,2,3,4.,MuddannaS.Rao1,4.,BingShuai1,2,3,4 1ResearchService,VeteransAffairsMedicalCentersofDurham,NorthCarolina,andTemple,Texas,UnitedStatesofAmerica,2InstituteforRegenerativeMedicine,Texas AMHealthScienceCenterCollegeofMedicineatScottWhite,Temple,Texas,UnitedStatesofAmerica,3DepartmentofMolecularandCellularMedicine,TexasAM HealthScienceCenterCollegeofMedicine,CollegeStation,Texas,UnitedStatesofAmerica,4DepartmentofSurgery(Neurosurgery),DukeUniversityMedicalCenter, Durham,NorthCarolina,UnitedStatesofAmerica Abstract Acute Seizure (AS) activity in young adult age conspicuously modifies hippocampal neurogenesis. This is epitomized by bothincreasedadditionofnewneuronstothegranulecelllayer(GCL)byneuralstem/progenitorcells(NSCs)inthedentate subgranular zone (SGZ), and greatly enhanced numbers of newly born neurons located abnormally in the dentate hilus (DH).Interestingly,ASactivityinoldagedoesnotinducesuchchangesinhippocampalneurogenesis.However,theeffect of AS activity on neurogenesis in the middle-aged hippocampus is yet to be elucidated. We examined hippocampal neurogenesisinmiddle-agedF344ratsafteracontinuousASactivityfor.4hrs,inducedthroughgradedintraperitoneal injectionsofthekainicacid.Welabelednewlyborncellsviadailyintraperitonealinjectionsofthe59-bromodeoxyuridine (BrdU)for12days,commencingfromthedayofinductionofASactivity.ASactivityenhancedtheadditionofnewlyborn BrdU+cellsby5.6foldandnewlybornneurons(expressingbothBrdUanddoublecortin[DCX])by2.2foldtotheSGZ-GCL. Measurement of the total number of DCX+ newly born neurons also revealed a similar trend. Furthermore, AS activity increasedDCX+newlybornneuronslocatedectopicallyintheDH(2.7foldincreaseand17%oftotalnewlybornneurons). This rate of ectopic migration is however considerably less than what was observed earlier for the young adult hippocampusaftersimilarASactivity.Thus,theplasticityofhippocampalneu