Non-Invasive Microstructure and Morphology Investigation of the Mouse Lung Qualitative Description and Quantitative Measurement 英文参考文献.docVIP

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Non-Invasive Microstructure and Morphology Investigation of the Mouse Lung Qualitative Description and Quantitative Measurement 英文参考文献.doc

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Non-Invasive Microstructure and Morphology Investigation of the Mouse Lung Qualitative Description and Quantitative Measurement 英文参考文献

Non-InvasiveMicrostructureandMorphology InvestigationoftheMouseLung:QualitativeDescription andQuantitativeMeasurement LuZhang,DongyueLi,ShuqianLuo* SchoolofBiomedicalEngineering,CapitalMedicalUniversity,Beijing,China Abstract Background:Earlydetectionoflungcancerisknowntoimprovethechancesofsuccessfultreatment.However,lungsare soft tissues with complex three-dimensional configuration. Conventional X-ray imaging is based purely on absorption resulting in very low contrast when imaging soft tissues without contrast agents. It is difficult to obtain adequate informationoflunglesionsfromconventionalX-rayimaging. Methods:Inthisstudy,arecentlyemergedimagingtechnique,in-lineX-rayphasecontrastimaging(IL-XPCI)wasused.This powerfultechniqueenabledhigh-resolutioninvestigationsofsofttissueswithoutcontrastagents.WeappliedIL-XPCIto observethelungsinanintactmouseforthepurposeofdefiningquantitativelythemicro-structuresinlung. Findings:Thethree-dimensionalmodelofthelungwassuccessfullyestablished,whichprovidedanexcellentviewoflung airways.WehighlightedtheuseofIL-XPCIinthevisualizationandassessmentofalveoliwhichhadrarelybeenstudiedin three dimensions (3D). The precise view of individual alveolus was achieved. The morphological parameters, such as diameterandalveolarsurfaceareaweremeasured.Theseparameterswereofgreatimportanceinthediagnosisofdiseases relatedtoalveolusandalveolarscar. Conclusion: Our results indicated that IL-XPCI had the ability to represent complex anatomical structures in lung. This offeredanewperspectiveonthediagnosisofrespiratorydiseaseandmayguidefutureworkinthestudyofrespiratory mechanismonthealveolilevel. Citation:ZhangL,LiD,LuoS(2011)Non-InvasiveMicrostructureandMorphologyInvestigationoftheMouseLung:QualitativeDescriptionandQuantitative Measurement.PLoSONE6(2):e17400.doi:10.1371/journal.pone.0017400 Editor:MatteoRini,JointResearchCentre-EuropeanCommission,Germany ReceivedOctober19,2010;AcceptedFebruary1,2011;PublishedFebruary25,2011 Copyright: ? 2011 Zhang et al