No Association of a Set of Candidate Genes on Haloperidol Side Effects 英文参考文献.docVIP

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No Association of a Set of Candidate Genes on Haloperidol Side Effects 英文参考文献.doc

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No Association of a Set of Candidate Genes on Haloperidol Side Effects 英文参考文献

NoAssociationofaSetofCandidateGeneson HaloperidolSideEffects AntonioDrago2.,InaGiegling1.,MartinScha¨fer1¤,AnnetteM.Hartmann1,Hans-Ju¨rgenMo¨ller1, DianaDeRonchi2,HansH.Stassen3,AlessandroSerretti2*,DanRujescu1 1Department of Psychiatry, Ludwig Maximilians University, Munich, Germany, 2Institute of Psychiatry, University of Bologna, Bologna, Italy, 3Psychiatric University Hospital,Zurich,Zurich,Switzerland Abstract Wepreviouslyinvestigatedasampleofpatientsduringanactivephaseofpsychosisinthesearchforgeneticpredictorsof haloperidolinducedsideeffects.Inthepresentworkweextendthegeneticassociationanalysistoawiderpanelofgenetic variations,including508variationslocatedin96genes.Theoriginalsampleincluded96patients.Anindependentgroupof 357patientsfromtheCATIEstudyservedasareplicationsample.Outcomesintheinvestigationsamplewerethevariation throughtimeof:1)theESRSandUKUtotalscores2)ESRSandUKUsubscales(neurologicandpsychicwereincluded)related to tremors and 3) ESRS and UKU subscales that do not relate to tremors. Outcome in the replication sample was the presencevsabsenceofmotoricsideeffectsfrombaselinetovisit1(,onemonthoftreatment)asassessedbytheAIMS scale test. Rs2242480 located in the CYP3A4 was associated with a different distribution of the UKU neurologic scores throughtime(permutatedp=0.047)alongwithatrendforadifferenthaloperidolplasmalevels(lowerinCCsubjects).This findingwasnotreplicatedintheCATIEsample.Inconclusion,wedidnotfindconclusiveevidenceforamajorassociation betweentheinvestigatedvariationsandhaloperidolinducedmotoricsideeffects Citation:DragoA,GieglingI,Scha¨fer M,HartmannAM,Mo¨llerH-J,etal.(2012)NoAssociationofaSetofCandidateGenesonHaloperidolSideEffects.PLoS ONE7(10):e44853.doi:10.1371/journal.pone.0044853 Editor:KatharinaDomschke,UniversityofWuerzburg,Germany ReceivedJune25,2012;AcceptedAugust8,2012;PublishedOctober15,2012 Copyright: ? 2012 Drago et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License,