None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis 英文参考文献.docVIP
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None of the Six SNPs of IL28B Could Predict Treatment Responses in Genotype 2 Chronic HCV Infected Patients by Propensity Score Matching Analysis 英文参考文献
NoneoftheSixSNPsofIL28BCouldPredictTreatment
ResponsesinGenotype2ChronicHCVInfectedPatients
byPropensityScoreMatchingAnalysis
Wen-JueiJeng1,4,Chun-YenLin1,2,Ji-YihChen2,3,Chang-WenHuang1,Chien-HaoHuang1,
I-ShyanSheen1,2
*
1Division of Hepatology, Department of Gastroenterology and Hepatology, Linkou Medical Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan, 2College of
Medicine,ChangGungUniversity,Taoyuan,Taiwan,3DepartmentofRheumatology,AllergyandImmunology,LinkouMedicalCenter,ChangGungMemorialHospital,
Taoyuan,Taiwan,4InstituteofClinicalMedicine,NationalYang-MingUniversity,Taipei,Taiwan
Abstract
BackgroundAims:Acombinationofpegylatedinterferon-alphaandribavirin(PR)isthestandardtherapyforpatients
withchronichepatitisC.Theimpactofpolymorphismofinterleukin-28B(IL28B)onsustainedvirologicalresponse(SVR)to
PR has been well documented in patients with CHC genotype-1 (GT1), but it is controversial in genotype-2 (GT2) CHC
patients.Thisstudyinvestigatedthepredictabilityofsixsinglenucleotidepolymorphisms(SNP)ofIL28Bonthetreatment
responsesofPRinpatientswithCHCGT2.
Method:197CHCGT2consecutivepatientswhoreceivedPRtreatmentinourprospectivecohortwereenrolled.HepatitisC
virus(HCV)genotyping,quantificationofHCV-RNAandgenotypingofthetenSNPsofIL28Bwereperformed.SixSNPsof
IL28Bwerechosenforanalysis.Thepropensityscorematching(PSM)analysiswasappliedusingpatientswithCHCGT1in
anotherprospectivecohortasapositivecomparisontoavoidcovariatebias.
Results:ThedistributionofthesixSNPswassimilarinGT1andGT2patients.FiveoftheseSNPshadstrongassociationwith
treatmentresponsesinGT1butnotinGT2patients.AfterPSManalysis,thesefiveSNPsstillshowedstrongassociationwith
rapidvirologicalresponse(RVR),cEVRandSVRinGT1andhadnoinfluenceinGT2patients.Furthermore,rnd
baselineviralloadwerethepredictorsforbothRVRandSVRinGT1patients.However,onlybaselineviralloadcouldpredict
RVRandSVRinGT2patients.Inaddition,inpatientswithoutRVR,rastheonlypredictorforSVRinGT1butno
predictorforSVRwasfoundinGT2.
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