Nuclear Envelope Remnants Fluid Membranes Enriched in STEROLS and Polyphosphoinositides 英文参考文献.docVIP
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Nuclear Envelope Remnants Fluid Membranes Enriched in STEROLS and Polyphosphoinositides 英文参考文献
NuclearEnvelopeRemnants:FluidMembranesEnriched
inSTEROLSandPolyphosphoinositides
MarieGarnier-Lhomme1,3,5,RichardD.Byrne1,4,TinaM.C.Hobday1,StephenGschmeissner2 ,Rudiger
Woscholski3,DominicL.Poccia4,ErickJ.Dufourc5,Banafshe′ Larijani1*
1CellBiophysicsLaboratory,Lincoln’sInnFieldsLaboratories,CancerResearchUK,London,UnitedKingdom,2ElectronMicroscopyUnit,Lincoln’sInnFieldsLaboratories,
CancerResearchUK,London,UnitedKingdom,3DivisionofCellandMolecularBiology,ImperialCollegeLondon,London,UnitedKingdom,4DepartmentofBiology,
AmherstCollege,Amherst,Massachusetts,UnitedStatesofAmerica,5UMR5248CNRS-Universite′ Bordeaux1-ENITAB,IECB,Pessac,France
Abstract
Background:Thecytoplasmofeukaryoticcellsisahighlydynamiccompartmentwheremembranesreadilyundergofission
andfusiontoreorganizethecytoplasmicarchitecture,andtoimport,exportandtransportvariouscargoswithinthecell.
Thedoublemembraneofthenuclearenvelopethatsurroundsthenucleus,segregatesthechromosomesfromcytoplasm
andregulatesnucleocytoplasmictransportthroughpores.Manydetailsofitsformationarestillunclear.Atfertilizationthe
sperm devoid of nuclear envelope pores enters the egg. Although most of the sperm nuclear envelope disassembles,
remnantsoftheenvelopeattheacrosomalandcentriolarfossaedonotandaresubsequentlyincorporatedintothenewly
formingmalepronuclearenvelope.Remnantsareconservedfromannelidtomammaliansperm.
Methodology/Principal Findings: Using lipid mass spectrometry and a new application of deuterium solid-state NMR
spectroscopy we have characterized the lipid composition and membrane dynamics of the sperm nuclear envelope
remnantsinisolatedspermnuclei.
Conclusions/Significance: Wereportnuclearenveloperemnantsarerelativelyfluidmembranesrichinsterols,devoidof
sphingomyelin,andhighlyenrichedinpolyphosphoinositidesandpolyunsaturatedphospholipids.Thelocalizationofthe
polybasic effector domain of MARCKS illustrates the non-nuclear aspect of the polyphosphoinositides. Based on their
atypical biophysical characteristics an
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