Ontology-Based Combinatorial Comparative Analysis of Adverse Events Associated with Killed and Live Influenza Vaccines 英文参考文献.docVIP

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Ontology-Based Combinatorial Comparative Analysis of Adverse Events Associated with Killed and Live Influenza Vaccines 英文参考文献.doc

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Ontology-Based Combinatorial Comparative Analysis of Adverse Events Associated with Killed and Live Influenza Vaccines 英文参考文献

Ontology-BasedCombinatorialComparativeAnalysisof AdverseEventsAssociatedwithKilledandLiveInfluenza Vaccines SiraratSarntivijai1,2,ZuoshuangXiang3,4,KerbyA.Shedden5,HowardMarkel6,GilbertS.Omenn1,2,8, BrianD.Athey1,2,7*,YongqunHe1,2,3,4 * 1NationalCenterforIntegrativeBiomedicalInformatics,UniversityofMichigan,AnnArbor,Michigan,UnitedStatesofAmerica,2CenterforComputationalMedicineand Bioinformatics,UniversityofMichigan,AnnArbor,Michigan,UnitedStatesofAmerica,3UnitofLaboratoryAnimalMedicine,UniversityofMichiganMedicalSchool,Ann Arbor,Michigan,UnitedStatesofAmerica,4DepartmentofMicrobiologyandImmunology,UniversityofMichiganMedicalSchool,AnnArbor,Michigan,UnitedStatesof America,5BiostatisticsDepartment,SchoolofPublicHealth,UniversityofMichigan,AnnArbor,Michigan,UnitedStatesofAmerica,6CenterfortheHistoryofMedicine and Department ofPediatrics,UniversityofMichigan, Ann Arbor,Michigan,UnitedStates ofAmerica, 7Department ofPsychiatry, UniversityofMichigan, Ann Arbor, Michigan,UnitedStatesofAmerica,8DepartmentsofInternalMedicineandHumanGenetics,andSchoolofPublicHealth,UniversityofMichigan,AnnArbor,Michigan, UnitedStatesofAmerica Abstract Vaccineadverseevents(VAEs)areadversebodilychangesoccurringaftervaccination.Understandingtheadverseevent(AE) profilesisacrucialsteptoidentifyseriousAEs.Twodifferenttypesofseasonalinfluenzavaccineshavebeenusedonthe market:trivalent(killed)inactivatedinfluenzavaccine(TIV)andtrivalentliveattenuatedinfluenzavaccine(LAIV).Different adverseeventprofilesinducedbythesetwogroupsofseasonalinfluenzavaccineswerestudiedbasedonthedatadrawn fromtheCDCVaccineAdverseEventReportSystem(VAERS).ExtractedfromVAERSwere37,621AEreportsforfourTIVs (Afluria,Fluarix,Fluvirin,andFluzone)and3,707AEreportsfortheonlyLAIV(FluMist).TheAEreportdatawereanalyzedby anovelcombinatorial,ontology-baseddetectionofAEmethod(CODAE).CODAEdetectsAEsusingProportionalReporting Ratio(PRR),Chi-squaresignificancetest,andbaselevelfiltration,andgroupsidentifiedAEsbyontology-basedhierarchical c