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Optimal selection on two quantitative trait loci with linkage 英文参考文献
Genet. Sel. Evol. 34(2002) 171–192
?INRA, EDP Sciences, 2002
DOI: 10.1051/gse:2002002
171
Original article
Optimalselectionontwoquantitativetrait
lociwithlinkage
JackC.M.DEKKERSa?,ReenaCHAKRABORTY a,
LaurenceMOREAUb
aDepartmentofAnimalScience,225KildeeHall,
IowaStateUniversityAmes,IA,50011,USA
bINRA-UPS-INA PG,Stationdegénétiquevégétale,
FermeduMoulon,91190Gif-sur-Yvette,France
(Received5February2001;accepted15October2001)
Abstract– Amathematicalapproachtooptimizeselectiononmultiplequantitativetraitloci
(QTL)andanestimateofresidualpolygeniceffectswasappliedtoselectionontwolinkedor
unlinkedadditiveQTL.Strategiestomaximizetotalorcumulativediscountedresponseoverten
generationswerecomparedtostandardQTLselectiononthesumofbreedingvaluesfortheQTL
andanestimatedbreedingvalueforpolygenes,andtophenotypicselection. Optimalselection
resultedingreaterresponsetoselectionthanstandardQTLorphenotypicselection.Tightlinkage
betweentheQTL(recombinationrate0.05)resultedinaslightlylowerresponseforstandard
QTLandphenotypicselectionbutinagreaterresponseforoptimalselection.Optimalselection
capitalizedonlinkagebyemphasizingselectiononfavorablehaplotypes. Whentheobjective
wastomaximizetotalresponseaftertengenerationsandQTLwereunlinked,optimalselection
increasedQTLfrequenciesto?xationinanearlinearmanner. Whenstartingfrequencieswere
equalforthetwoQTL,equalemphasiswasgiventoeachQTL,regardlessofthedifference
ineffectsoftheQTLandregardlessofthelinkage,buttheemphasisgiventoeachofthetwo
QTLwasnotadditive. Theseresultsdemonstratetheabilityofoptimalselectiontocapitalize
oninformationonthecomplexgeneticbasisofquantitativetraitsthatisforthcoming.
selection/marker-assistedselection/quantitativetraitloci/optimization
1.INTRODUCTION
The advent of molecular genetics has opened opportunities to enhance
selectionforquantitativetraitsbyincorporatinginformationontheidenti?ed
quantitativetraitloci(QTL)oronthegeneticmarkersthatarelinkedtoQTL
ingeneticimprovementprograms. Inwhatfollows,wewillrefe
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