Optimization of the Balanced Steady State Free Precession (bSSFP) Pulse Sequence for Magnetic Resonance Imaging of the Mouse Prostate at 3T 英文参考文献.docVIP

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Optimization of the Balanced Steady State Free Precession (bSSFP) Pulse Sequence for Magnetic Resonance Imaging of the Mouse Prostate at 3T 英文参考文献.doc

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Optimization of the Balanced Steady State Free Precession (bSSFP) Pulse Sequence for Magnetic Resonance Imaging of the Mouse Prostate at 3T 英文参考文献

OptimizationoftheBalancedSteadyStateFree Precession(bSSFP)PulseSequenceforMagnetic ResonanceImagingoftheMouseProstateat3T ChristianeL.Mallett1,2*,PaulaJ.Foster1,2 1DepartmentofMedicalBiophysics,TheUniversityofWesternOntario,London,Ontario,Canada,2ImagingResearchLaboratories,RobartsResearchInstitute,London, Ontario,Canada Abstract Introduction:MRIcanbeusedtonon-invasivelymonitortumourgrowthandresponsetotreatmentinmousemodelsof prostatecancer,particularlyforlongitudinalstudiesoforthotopically-implantedmodels.Wehaveoptimizedthebalanced steady-statefreeprecession(bSSFP)pulsesequenceformouseprostateimaging. Methods:Phasecycling,excitations,flipangleandreceiverbandwidthparameterswereoptimizedforsignaltonoiseratio andcontrasttonoiseratiooftheprostate.TheoptimizedbSSFPsequencewascomparedtoT1-andT2-weightedspinecho sequences. Results: SNR and CNR increased with flip angle. As bandwidth increased, SNR, CNR and artifacts such as chemical shift decreased.Thefinal optimizedsequencewas4 PC,2NEX, FA50u,BW662.5kHzandtook14–26minuteswith200mm isotropicresolution.TheSNRefficiencyofthebSSFPimageswashigherthanforT1WSEandT2WSE.CNRwashighestfor T1WSE, followedclosely bybSSFP,withtheT2WSE havingthelowest CNR.With thebSSFP imagesthewholebody and organsofinterestincludingrenal,iliac,inguinalandpopliteallymphnodeswerevisible. Conclusion: We were able to obtain fast, high-resolution, high CNR images of the healthy mouse prostate with an optimizedbSSFPsequence. Citation:MallettCL,FosterPJ(2011)OptimizationoftheBalancedSteadyStateFreePrecession(bSSFP)PulseSequenceforMagneticResonanceImagingofthe MouseProstateat3T.PLoSONE6(4):e18361.doi:10.1371/journal.pone.0018361 Editor:YiWang,CornellUniversity,UnitedStatesofAmerica ReceivedOctober26,2010;AcceptedMarch3,2011;PublishedApril8,2011 Copyright: ? 2011 Mallett, Foster. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricteduse,distribution,andreproductioninanymedium,