Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance 英文参考文献.docVIP

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Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance 英文参考文献.doc

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Optimizing purebred selection for crossbred performance using QTL with different degrees of dominance 英文参考文献

Genet.Sel.Evol.36(2004)297–324 c INRA,EDPSciences,2004 DOI:10.1051/gse:2004003 297 Originalarticle Optimizingpurebredselectionforcrossbred performanceusingQTLwithdi?erent degreesofdominance JackC.M.D???????,ReenaC?????????? DepartmentofAnimalScience,225CKildeeHall,IowaStateUniversity,Ames, IA,50011,USA (Received9April2003;accepted17December2003) Abstract–Amethodwasdevelopedtooptimizesimultaneousselectionforaquantitativetrait withaknownQTLwithinamaleandafemalelinetomaximizecrossbredperformancefrom atwo-waycross.Strategiestomaximizecumulativediscountedresponseincrossbredperfor- manceovertengenerationswerederivedbyoptimizingweightsinanindexofaQTLandphe- notype. Strategieswerecompared toselectiononpurebred phenotype. Extraresponses were limited for QTL with additive and partial dominance e?ects, but substantial for QTL with over-dominance,forwhichoptimalQTLselectionresultedindi?erentialselectioninmaleand female lines to increase the frequency of heterozygotes and polygenic responses. For over- dominant QTL,maximizationofcrossbredperformance onegeneration atatimeresultedin similarresponsesasoptimizationacrossallgenerationsandsimultaneousoptimalselectionin amaleandfemalelineresultedingreaterresponsethanoptimalselectionwithinasingleline withoutcrossbreeding.Resultsshowthatstrategicuseofinformationonover-dominantQTL canenhancecrossbredperformancewithoutcrossbredtesting. crossbreeding/selection/quantitativetraitloci/markerassistedselection 1. INTRODUCTION Inmostlivestockproductionsystems,crossbredsareusedforcommercial productiontocapitalizeonheterosisandcomplementarityandtheaimofse- lectionwithinpure-linesistomaximizecrossbredperformance.Selectionis, however,withinpure-linesandprimarilybasedonpurebreddata,whichmay notmaximizegeneticprogressincrossbredperformance[21].Severaltheoret- icalstudieshaveshownthatselectiononacombinationofcrossbredandpure- bredperformancecanresultingreaterresponsesincrossbredperformance,in particularifgeneswithcompleteorover-dominancea?ectthet