Optimization of Cardiovascular Stent against Restenosis Factorial Design-Based Statistical Analysis of Polymer Coating Conditions 英文参考文献.docVIP

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Optimization of Cardiovascular Stent against Restenosis Factorial Design-Based Statistical Analysis of Polymer Coating Conditions 英文参考文献.doc

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Optimization of Cardiovascular Stent against Restenosis Factorial Design-Based Statistical Analysis of Polymer Coating Conditions 英文参考文献

OptimizationofCardiovascularStentagainstRestenosis: FactorialDesign-BasedStatisticalAnalysisofPolymer CoatingConditions GayathriAcharya1,ChiH.Lee1*.,YugyungLee2*. 1DivisionofPharmaceuticalSciences,SchoolofPharmacy,UniversityofMissouri-KansasCity,KansasCity,Missouri,UnitedStatesofAmerica,2DepartmentofComputer ScienceandElectricalEngineering,SchoolofComputingandEngineering,UniversityofMissouri-KansasCity,KansasCity,Missouri,UnitedStatesofAmerica Abstract Theobjectiveofthisstudywastooptimizethephysicodynamicconditionsofpolymericsystemasacoatingsubstratefor drugelutingstentsagainstrestenosis.AsNitricOxide(NO)hasmultifunctionalactivities,suchasregulatingbloodflowand pressure, and influencing thrombus formation, a continuous and spatiotemporal delivery of NO loaded in the polymer basednanoparticlescouldbeaviableoptiontoreduceandpreventrestenosis.ToidentifythemostsuitablecarrierforS- Nitrosoglutathione(GSNO),aNOprodrug,stentswerecoatedwithvariouspolymers,suchaspoly(lactic-co-glycolicacid) (PLGA),polyethyleneglycol(PEG)andpolycaprolactone(PCL),usingsolventevaporationtechnique.Fullfactorialdesignwas used to evaluate theeffects of theformulation variables in polymer-based stent coatings on theGSNO release rate and weightlossrate.Theleastsquareregressionmodelwasusedfordataanalysisintheoptimizationprocess.Thepolymer- coatedstentswerefurtherassessedwithDifferentialscanningcalorimetry(DSC),Fouriertransforminfraredspectroscopy analysis(FTIR),Scanningelectronmicroscopy(SEM)imagesandplateletadhesionstudies.StentscoatedwithPCLmatrix displayedmoresustainedandcontrolleddrugreleaseprofilesthanthosecoatedwithPLGAandPEG.Stentscoatedwith PCL matrix showed the least platelet adhesion rate. Subsequently, stents coated with PCL matrix were subjected to the furtheroptimizationprocessesforimprovementofsurfacemorphologyandenhancementofthedrugreleaseduration.The resultsofthisstudydemonstratedthatPCLmatrixcontainingGSNOisapromisingsystemforstentsurfacecoatingagainst restenosis. Citation:AcharyaG